ArticleCerebellum (London, England)2019
Fall Risk in Relation to Individual Physical Activity Exposure in Patients with Different Neurodegenerative Diseases: a Pilot Study.
Article in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Performance of digital technologies in assessing fall risks among older adults with cognitive impairment: a systematic review.GeroScience · 2024Pooled it
- Identification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Pooled it
- Differential Effects of Cerebellar Transcranial Direct Current Stimulation with Gait Training on Functional Mobility, Balance, and Ataxia Symptoms.Cerebellum (London, England) · 2024Trial
- Falls Risk in Relation to Activity Exposure in High-Risk Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- A prospective analysis of falls in Parkinson's disease: Does physical capacity moderate the relationship between walking amount and falls rates?Journal of Parkinson's disease · 2026Article
- Real-world feasibility of privacy-preserving, non-wearable AI for real-time fall detection with disease-specific video classification in parkinsonian syndromes: a proof-of-concept clinical study.Frontiers in neurology · 2026Article
- Pathway to Regulatory Approval of Digital Health Technologies in Progressive Supranuclear Palsy: A Scoping Review.Brain sciences · 2025Review
- Determining the Importance of Clinical Modalities for NeuroDegenerative Disorders and Risk of Patient Injury Using Machine Learning and Survival Analysis.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025Article
- Assessing the clinical utility of inertial sensors for home monitoring in Parkinson's disease: a comprehensive review.NPJ Parkinson's disease · 2024Article
- Multimodal Mobility Assessment Predicts Fall Frequency and Severity in Cerebellar Ataxia.Cerebellum (London, England) · 2023Article
- Energy expenditure, body composition and dietary habits in progressive supranuclear palsy.Journal of neurology · 2022Article
- Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes.NPJ digital medicine · 2021Article
- Fall prediction in neurological gait disorders: differential contributions from clinical assessment, gait analysis, and daily-life mobility monitoring.Journal of neurology · 2021Article
- Independent domains of daily mobility in patients with neurological gait disorders.Journal of neurology · 2020Article
- How often are patients with progressive supranuclear palsy really falling?Journal of neurology · 2019Article
- Wearable sensors and features for diagnosis of neurodegenerative diseases: A systematic review.Digital healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Falls in patients with neurodegenerative diseases (NDDs) have enormous detrimental consequences. A better understanding of the interplay between physical activity (PA) and fall risk might help to reduce fall frequency. We aimed to investigate the association between sensor-based PA and fall risk in NDDs, using "falls per individual PA exposure time" as a novel measure. Eighty-eight subjects (n = 31 degenerative ataxia (DA), n = 14 Parkinson's disease (PD), n = 12 progressive supranuclear palsy (PSP) and 31 healthy controls) were included in this pilot study. PA was recorded in free-living environments with three-axial accelerometers (activPAL™) over 7 days. Falls were prospectively assessed over 12 months. Fall incidence was calculated by (i) absolute number of falls per person years (py) and (ii) falls per exposure to individual PA. Absolute fall incidence was high in all three NDDs, with differing levels (DA, 9 falls/py; PD, 14 falls/py; PSP, 29 falls/py). Providing a more fine-grained view on fall risk, correction for individual exposure to PA revealed that measures of low walking PA were associated with higher fall incidence in all three NDDs. Additionally, higher fall incidence was associated with more sit-to-stand transfers in PD and longer walking bouts in PSP. Our results suggest that low walking PA is a risk factor for falls in DA, PD and PSP, indicating the potential benefit of increasing individual PA in these NDDs to reduce fall risk. Moreover, they show that correction for individual exposure to PA yields a more differentiated view on fall risk within and across NDDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.