SynthesisJournal of autism and developmental disorders2019
Toddler Screening for Autism Spectrum Disorder: A Meta-Analysis of Diagnostic Accuracy.
Synthesis in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Strategies for addressing the needs of children with or at risk of developmental disabilities in early childhood by 2030: a systematic umbrella review.BMC medicine · 2024Pooled it
- Sensitivity and Specificity of the Modified Checklist for Autism in Toddlers (Original and Revised): A Systematic Review and Meta-analysis.JAMA pediatrics · 2023Pooled it
- Trial
- Bridging Languages, Broadening Access: Examining an Observation-Based Autism Assessment with a Latinx Sample.Journal of autism and developmental disorders · 2026Article
- Performance of Autism Screening and Diagnostic Instruments Among Children with ADHD: A Systematic Review.Journal of autism and developmental disorders · 2025Article
- Clinical utility and psychometric properties of tools for early detection of developmental concerns and disability in young children: A scoping review.Developmental medicine and child neurology · 2025Article
- Autism Spectrum Disorder in Children: Early Signs and Therapeutic Interventions.Children (Basel, Switzerland) · 2024Review
- Medical Home, Developmental Monitoring/Screening, and Early Autism Identification.Journal of autism and developmental disorders · 2024Article
- Validity and feasibility of using the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) in primary care clinics in Singapore.Autism : the international journal of research and practice · 2024Article
- The influence of loss to follow-up in autism screening research: Taking stock and moving forward.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Exploring public health nurses' acceptability of clinical assessment tools in a Norwegian child health centre.Primary health care research & development · 2024Article
- Malay translation and validation of modified checklist for autism in toddlers, revised with follow-up (M-CHAT-R/F).Frontiers in pediatrics · 2024Article
- Balancing Fidelity and Flexibility: Usual Care for Young Children With an Increased Likelihood of Having Autism Spectrum Disorder Within an Early Intervention System.Journal of autism and developmental disorders · 2023Article
- The implementation of the screening tool for autism in toddlers in Part C early intervention programs: An 18-month follow-up.Autism : the international journal of research and practice · 2023Article
- Tools for early screening of autism spectrum disorders in primary health care - a scoping review.BMC primary care · 2022Article
- Are Developmental Monitoring and Screening Better Together for Early Autism Identification Across Race and Ethnic Groups?Journal of autism and developmental disorders · 2022Article
- A feasibility study of a new instrument for detection of autism signs in preschool settings. Psychometric properties of the joint attention observation schedule preschool (JA-OBS preschool).Frontiers in child and adolescent psychiatry · 2022Article
- The Toddler Autism Symptom Inventory: Use in diagnostic evaluations of toddlers.Autism : the international journal of research and practice · 2021Article
- Associations Among Referral Concerns, Screening Results, and Diagnostic Outcomes of Young Children Assessed in a Statewide Early Autism Evaluation Network.The Journal of pediatrics · 2021Article
- Editorial S.I: Early Identification in Autism Spectrum Disorders: The Present and Future, and Advances in Early Identification.Journal of autism and developmental disorders · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
Great efforts focus on early detection of autism spectrum disorder, although some scientists and policy-makers have questioned early universal screening. The aim of this meta-analysis was to evaluate the diagnostic accuracy of the different screening tools. Several electronic databases were used to identify published studies. A Bayesian model was used to estimate the screening accuracy. The pooled sensitivity was 0.72 (95% CI 0.61-0.81), and the specificity was 0.98 (95% CI 0.97-0.99). Subgroup analyses to remove heterogeneity indicated sensitivity was 0.77 (95% CI 0.69-0.84), and specificity was 0.99 (95% CI 0.97-0.99; SD ≤ 0.01). Level 1 screening tools for ASD showed consistent statistically significant results and therefore are adequate to detect autism at 14-36 months.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.