ArticleEuropean radiology2019
Uncontrolled asthma phenotypes defined from parameters using quantitative CT analysis.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Glucocorticoid-Induced TNFR-Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children.Pediatric discovery · 2026Article
- Small Airway Function as an Indicator for Persistent Airflow Limitation Asthma: A Retrospective Study.The clinical respiratory journal · 2026Article
- Back to the future in asthma imaging: quantitative assessment and new perspectives.La Radiologia medica · 2026Review
- Quantitative Computed Tomographic Clusters in C-BIOPRED Asthma Cohort: Association with Sputum Proteomics.MedComm · 2025Article
- Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review.Journal of asthma and allergy · 2025Review
- Increased Muc5AC and Decreased Ciliated Cells in Severe Asthma Partially Restored by Inhibition of IL-4Rα Receptor.American journal of respiratory and critical care medicine · 2024Article
- Increased expression of cathepsin C in airway epithelia exacerbates airway remodeling in asthma.JCI insight · 2024Article
- Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics.The European respiratory journal · 2024Article
- Novel Lung Growth Strategy with Biological Therapy Targeting Airway Remodeling in Childhood Bronchial Asthma.Children (Basel, Switzerland) · 2022Review
- Phenotypic clusters on computed tomography reflects asthma heterogeneity and severity.The World Allergy Organization journal · 2022Article
- Novel imaging phenotypes of naïve asthma patients with distinctive clinical characteristics and T2 inflammation traits.Therapeutic advances in chronic disease · 2022Article
- Status and prospects: personalized treatment and biomarker for airway remodeling in asthma.Journal of thoracic disease · 2020Review
- Airway Remodeling in Asthma.Frontiers in medicine · 2020Review
- Association of Total Airway Count on Computed Tomography with Pulmonary Function Decline in Early-Stage COPD: A Population-Based Prospective Cohort Study.International journal of chronic obstructive pulmonary diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveAsthma is a heterogeneous disease with diverse clinical phenotypes that have been identified via cluster analyses. However, the classification of phenotypes based on quantitative CT (qCT) is poorly understood. The study was conducted to investigate CT determination of uncontrolled asthma phenotypes.
methodsSixty-five patients with uncontrolled asthma (37 with severe asthma, 28 with non-severe asthma) underwent detailed clinical, laboratory, and pulmonary function tests, as well as qCT analysis. Twenty-five healthy subjects were also included in this study and underwent clinical physical examinations, pulmonary function tests, and low-dose CT scans.
resultsThe mean lumen area/body surface area ratio was smaller in patients with severe uncontrolled asthma compared with that in healthy subjects (9.84 mm
conclusionsThere was obvious air trapping and proximal airway remodeling in patients with severe uncontrolled asthma. The three CT-determined uncontrolled asthma phenotypes might reflect underlying mechanisms of disease in patient stratification and in the different stages of disease development. KEY POINTS: • Obvious air trapping and proximal airway remodeling were present in patients with severe uncontrolled asthma. • CT air trapping indices showed a good correlation with disease duration, total IgE, atopy, and OCS and ICS doses, and were even more strongly correlated with clinical lung function. • Three CT-determined uncontrolled asthma phenotypes were identified, which might reflect underlying mechanisms of disease in patient stratification and in the different stages of disease development.
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