ArticleEuropean radiology2019
The value of MR T2* measurements in normal and osteoarthritic knee cartilage: effects of age, sex, and location.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 19 citations in OpenAlex.
- Association of patellofemoral malalignment with early trochlear and patellar chondromalacia: a prospective T2* mapping study.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Article
- Exploring the asynchronous changes of articular cartilage and osteochondral junction in knee osteoarthritis based on T2 mapping and ultrashort echo time imaging: a pilot study.Quantitative imaging in medicine and surgery · 2025Article
- Gaining Insight into Updated MR Imaging for Quantitative Assessment of Cartilage Injury in Knee Osteoarthritis.Current rheumatology reports · 2024Review
- Cartilage compositional MRI-a narrative review of technical development and clinical applications over the past three decades.Skeletal radiology · 2024Review
- Effects of long-term running on the structure and biochemical composition of knee cartilage in males: a cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- Association between quadriceps fat pad edema and patellofemoral osteoarthritis: a quantitative Q-Dixon-based magnetic resonance imaging (MRI) analysis.Quantitative imaging in medicine and surgery · 2024Article
- A higher intramuscular fat in vastus medialis is associated with functional disabilities and symptoms in early stage of knee osteoarthritis: a case-control study.Arthritis research & therapy · 2023Article
- Magnetic resonance imaging R2* sequences can better detect microstructural cartilage changes than T2 mapping in cynomolgus monkeys with limited knee kinematics: preliminary imaging findings.BMC musculoskeletal disorders · 2022Article
- High resolution T2∗ mapping in assessment of knee articular cartilage on 3T MRI.Journal of clinical orthopaedics and trauma · 2022Article
- Advances in the Treatment of Partial-Thickness Cartilage Defect.International journal of nanomedicine · 2022Review
- MRI evaluation of articular cartilage in patients with juvenile osteochondritis dissecans (JOCD) using T2∗ mapping at 3T.Osteoarthritis and cartilage · 2020Article
- Morphological MRI of knee cartilage: repeatability and reproducibility of damage evaluation and correlation with gross pathology examination.European radiology · 2020Article
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesOur aim was to investigate the role of age, sex, and location on MR T2* values of the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA).
methodsA total of 100 participants, including 40 with OA and 60 asymptomatic controls, were enrolled in this study. Patients with OA were compared to age- (≥ 41 years old) and sex-matched controls. Controls were divided by age (aged 21-40 years, 41-60, ≥ 61). T2* values were acquired using a T2*-weighted fast gradient-echo sequence and a 1.5-T MRI scanner. T2* values of the femoral and tibial cartilages at the weight-bearing areas were obtained for comparisons.
resultsThe T2* values significantly increased with age and were significantly higher in the medial femoral cartilage (35.96 ± 4.06 and 31.85 ± 2.44 ms), medial tibial cartilage (30.95 ± 2.87 and 28.24 ± 1.74 ms), and lateral femoral cartilage (33.90 ± 3.15 and 31.51 ± 2.28 ms) in OA patients versus age- and sex-matched controls. Among OA patients, the T2* values for women exceed those in men in the medial femoral cartilage (37.59 ± 4.43 and 34.16 ± 2.63 ms) and medial tibial cartilage (32.17 ± 2.59 and 29.62 ± 2.53 ms; p < 0.01). Correlations were found between the Lequesne index and the T2* values for the medial femoral cartilage (r = 0.636, p < 0.001) and the medial tibial cartilage (r = 0.433, p = 0.005).
conclusionCartilage T2* values tend to increase with age and are useful in assessing cartilage degeneration in early OA. KEY POINTS: • Age, sex, and location have important effects on cartilage T2* values at the knee. • MR T2* measurements are useful toward assessing cartilage degeneration. • The medial femoral and tibial cartilage T2* values correlate well with disease severity.
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