Evidence map›Paper›PMID 30617318›Full record

ArticleNature medicine2019

Screening for cardiac contractile dysfunction using an artificial intelligence-enabled electrocardiogram.

Zachi I Attia, Suraj Kapa, Francisco Lopez-Jimenez, Paul M McKie, Dorothy J Ladewig, Gaurav Satam, Patricia A Pellikka, Maurice Enriquez-Sarano, Peter A Noseworthy, Thomas M Munger and 4 more

6 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 652 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
652citing papers in PubMed, 2 pooled it
57.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05442203 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Electrocardiogram-based Artificial Intelligence-assisted Detection of Heart Disease

TypeinterventionalSponsorTempus AIRan2022 to 2025Enrolled1,000ConditionsAtrial Fibrillation, Structural Heart DiseaseArmsZio Patch Monitor, Echocardiogram
NCT05861115 nacompletednot on this mapstarted 2023, after this paper: background citation

A Study to Evaluate Accuracy and Validity of the "Chang Gung" Ventricular Systolic Dysfunction Screening Software

TypeinterventionalSponsorChang Gung Memorial HospitalRan2023 to 2023Enrolled1,172ConditionsLeft Ventricular Systolic DysfunctionArms"Chang Gung" Ventricular Systolic Dysfunction Screening Software
NCT05960890 narecruitingnot on this mapstarted 2023, after this paper: background citation

Cohort Study of Chronic Heart Failure

TypeinterventionalSponsorJiangsu Taizhou People's HospitalRan2023 to 2028Enrolled1,000ConditionsHeart FailureArmsRemote monitoring assisted by community physicians
NCT07087613 recruitingnot on this mapstarted 2025, after this paper: background citation

Deep Learning for Detection of Pulmonary Hypertension and Reduced Left Ventricular Ejection Fraction Using a Combined Digital Stethoscope and Three-lead Electrocardiogram

TypeobservationalSponsorEko Devices, Inc.Ran2025 to 2027Enrolled3,850ConditionsHypertension, Pulmonary, Heart Failure With Reduced Ejection FractionArmsEko CORE 500 Digital Stethoscope
NCT07636759 recruitingnot on this mapstarted 2026, after this paper: background citation

Prospective Observational Cohort Study of Deep Learning-based ECG Algorithm for Detecting Left Ventricular Systolic Dysfunction

Typeobservational_patient_registrySponsorAjou University School of MedicineRan2026 to 2027Enrolled1,500ConditionsHF - Heart FailureArmsNone-placebo
NCT07775976 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways

TypeobservationalSponsorPeerbridge Health, IncRan2026 to 2030Enrolled1,000ConditionsCardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular AbnormalitiesArmsCOR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
3 · Its place in the literature

Who cites it

652 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,249 citations in OpenAlex.

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  20. [AI-Assisted ECG diagnostics : Classical test statistics still apply].Herzschrittmachertherapie & Elektrophysiologie · 2026
    Review

592 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Zachi I AttiaCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Suraj KapaCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Francisco Lopez-JimenezCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Paul M McKieCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-0019-4768
Dorothy J LadewigBusiness Development, Mayo Clinic, Rochester, MN, USA.
Gaurav SatamBusiness Development, Mayo Clinic, Rochester, MN, USA.
Patricia A PellikkaCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6800-3521
Maurice Enriquez-SaranoCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Peter A NoseworthyCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4308-0456
Thomas M MungerCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Samuel J AsirvathamCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.
Christopher G ScottHealth Sciences Research, Mayo Clinic, Rochester, MN, USA.
Rickey E CarterHealth Sciences Research, Mayo Clinic, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0002-0818-273X
Paul A FriedmanCardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. friedman.paul@mayo.edu.ORCID http://orcid.org/0000-0001-5052-2948
Mayo Clinic in Arizona · USMayo Clinic · USMayo Clinic in Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asymptomatic left ventricular dysfunction (ALVD) is present in 3-6% of the general population, is associated with reduced quality of life and longevity, and is treatable when found

Indexed as

Artificial IntelligenceElectrocardiographyMass ScreeningMyocardial ContractionAdultAgedAged, 80 and overFemaleHeartHumansMaleMiddle AgedNeural Networks, ComputerROC CurveSensitivity and SpecificityStroke Volume

Identifiers

PMID30617318
OpenAlexW2901226889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.