Evidence map›Paper›PMID 30617302›Full record

ArticleMucosal immunology2019

The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model.

J Sung, C P Sodhi, L Voltaggio, X Hou, H Jia, Q Zhou, D Čiháková, D J Hackam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Biomedical advances and future prospects of high-precision three-dimensional radiotherapy and four-dimensional radiotherapy.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023
    Article
  4. Article
  5. Cells · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

J SungInstitute of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
C P SodhiDivision of Pediatric Surgery, Johns Hopkins Children's Center and Department of Surgery, Baltimore, MD, USA.
L VoltaggioDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
X HouW. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
H JiaDivision of Pediatric Surgery, Johns Hopkins Children's Center and Department of Surgery, Baltimore, MD, USA.
Q ZhouDivision of Pediatric Surgery, Johns Hopkins Children's Center and Department of Surgery, Baltimore, MD, USA.
D ČihákováDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
D J HackamInstitute of Genetic Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA. dhackam1@jhmi.edu.

Funding

TLR4 Signaling in the Pathogenesis of Surgical Necrotizing EnterocolitisR01GM078238 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HACKAM, DAVID J · 2006 to 2019
$3.9M
Modulation of TLR4 and TLR9 Signaling in NECR01DK083752 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HACKAM, DAVID J · 2008 to 2016
$3.4M
Maternal-Fetal AHR Signaling in the Pathogenesis and Treatment of Necrotizing EnterocolitisR01DK117186 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HACKAM, DAVID J · 2018 to 2021
$1.5M
NIDDK NIH HHS R01 DK083752NIDDK NIH HHS R01 DK117186NIGMS NIH HHS R01 GM078238
6 · The paper itself

Abstract

Mucosal healing occurs through migration and proliferation of cells within injured epithelium, yet these processes may be inadequate for mucosal healing after significant injury where the mucosa is denuded. We hypothesize that extra-intestinal cells can contribute to mucosal healing after injury to the small and large intestine. We generated parabiotic pairs between wild-type and tdTomato mice, which were then subjected to radiation-induced enteritis and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. We now show that as compared with singleton mice, mice with a parabiotic partner were protected against intestinal damage as revealed by significantly reduced weight loss, reduced expression of pro-inflammatory cytokines, reduced enterocyte apoptosis, and improved crypt proliferation. Donor cells expressed CD45

Indexed as

Cell MovementAnimalsAntigens, LyBone Marrow CellsColitisDisease Models, AnimalEnteritisFemaleHumansIntestinal MucosaIntestine, SmallMembrane ProteinsMiceMice, Inbred C57BLMice, TransgenicParabiosisAntigens, LyCXCR4 protein, mouseLy6a protein, mouseMembrane ProteinsReceptors, CXCR4Trinitrobenzenesulfonic Acid

Identifiers

PMID30617302
PMCPMC6445662

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.