Evidence map›Paper›PMID 30617275›Full record

SynthesisMolecular psychiatry2020

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

A Mesut Erzurumluoglu, Mengzhen Liu, Victoria E Jackson, Daniel R Barnes, Gargi Datta, Carl A Melbourne, Robin Young, Chiara Batini, Praveen Surendran, Tao Jiang and 167 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 5 pooled it
15.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. A blood- and brain-based EWAS of smoking.Nature communications · 2025
    Article
  14. Multivariate Bayesian variable selection for multi-trait genetic fine mapping.Journal of the Royal Statistical Society. Series C, Applied statistics · 2025
    Article
  15. Article
  16. Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  17. Shared genetic basis connects smoking behaviors and bone health: insights from a genome-wide cross-trait analysis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024
    Article
  18. Article
  19. Article
  20. Review

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

177 authors at 20 institutions in 18 countries.

A Mesut Erzurumluoglu *Department of Health Sciences, University of Leicester, Leicester, UK.
Mengzhen Liu *Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Victoria E Jackson *Department of Health Sciences, University of Leicester, Leicester, UK.
Daniel R BarnesMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Gargi DattaDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Carl A MelbourneDepartment of Health Sciences, University of Leicester, Leicester, UK.
Robin YoungMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Chiara BatiniDepartment of Health Sciences, University of Leicester, Leicester, UK.
Praveen SurendranMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Tao JiangMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Sheikh Daud AdnanNational Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh.
Saima AfaqDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Arpana AgrawalDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
Elisabeth AltmaierResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Antonis C AntoniouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Folkert W AsselbergsDepartment of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Clemens BaumbachResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Laura BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Sarah BertelsenDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Michiel L BotsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands.
David M BrazelInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Chu ChenPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Janie CorleyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Yi-Ling ChouDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
Sean P DavidDepartment of Medicine, Stanford University, Stanford, CA, USA.
Rudolf A de BoerDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Christiaan A de LeeuwDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Joe G DennisCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Anna F DominiczakInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge Centre, University of Cambridge, Cambridge, CB1 8RN, UK.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Charles EatonDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Paul ElliottDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Alison GoateDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jian GongPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, 17475, Greifswald, Germany.
Jeff HaesslerPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Christopher HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Göran HallmansDepartment of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden.
Anke R HammerschlagDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Andrew HattersleyGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Andrew HeathDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
Chris HsuUniversity of Southern California, California, CA, USA.
William G IaconoDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Stavroula KanoniWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Manav KapoorDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Sharon L KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Jukka KonttoDepartment of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, Middlesex, UB1 3HW, UK.
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kari KuulasmaaDepartment of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Markku LaaksoUniversity of Eastern Finland, Finland, Finland.
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Claudia LangenbergMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Nhung LeDepartment of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Guillaume LettreMontreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada.
Anu LoukolaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Jian'an LuanMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Pamela A F MaddenDepartment of Psychiatry, Washington University, St. Louis, MO, USA.
Massimo ManginoNIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, SE1 9RT, UK.
Riccardo E MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Eirini MarouliWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Jonathan MartenMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Nicholas G MartinQueensland Institute for Medical Research, Brisbane, Australia.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Evelin MihailovEstonian Genome Center, University of Tartu, Tartu, Estonia.
Alireza MoayyeriInstitute of Health Informatics, University College London, London, UK.
Marie MoitryDepartment of Epidemiology and Public health, University Hospital of Strasbourg, Strasbourg, France.
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Aliya NaheedInitiative for Noncommunicable Diseases, Health Systems and Population Studies Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475, Greifswald, Germany.
Matthew J NevilleOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Sune Fallgaard NielsenDepartment of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 74, DK-2730, Herlev, Denmark.
Kari NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
Markus PerolaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Paul D P PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Giorgio PistisIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Tinca J PoldermanDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Danielle PosthumaDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, Netherlands.
Neil PoulterInternational Centre for Circulatory Health, Imperial College London, London, UK.
Beenish QaiserInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Asif RasheedCentre for Non-Communicable Diseases, Karachi, Pakistan.
Alex ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Frida RenströmGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-214 28, Malmö, Sweden.
John RiceDepartments of Psychiatry and Mathematics, Washington University St. Louis, St. Louis, MO, USA.
Rebecca RohdeUniversity of North Carolina, Chapel Hill, NC, USA.
Olov RolandssonDepartment of Public Health & Clinical Medicine, Section for Family Medicine, Umeå universitet, SE, 90185, Umeå, Sweden.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, LE3 9QP, UK.
Maria SamuelCentre for Non-Communicable Diseases, Karachi, Pakistan.
David SchlessingerNational Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Steven H ScholteDepartment of Psychology, University of Amsterdam & Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands.
Robert A ScottMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Peter SeverNational Heart and Lung Institute, Imperial College London, London, W12 0NN, UK.
Yaming ShaoUniversity of North Carolina, Chapel Hill, NC, USA.
Nick ShrineDepartment of Health Sciences, University of Leicester, Leicester, UK.
Jennifer A SmithDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Kathleen StirrupsWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
Danielle StramDepartment of Preventative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Heather M StringhamDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Ioanna TachmazidouWellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
Jean-Claude TardifMontreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada.
Deborah J ThompsonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Hilary A TindleDepartment of Medicine, Vanderbilt University, Nashville, TN, USA.
Vinicius TraganteDepartment of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University, 3508GA, Utrecht, The Netherlands.
Stella TrompetDepartment of gerontology and geriatrics, Leiden University Medical Center, Leiden, The Netherlands.
Valerie TurcotMontreal Heart Institute, Montreal, Quebec, H1T 1C8, Canada.
Jessica TyrrellGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Ilonca VaartjesJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508GA, Utrecht, The Netherlands.
Andries R van der LeijDepartment of Psychology, University of Amsterdam & Amsterdam Brain and Cognition, University of Amsterdam, Amsterdam, Netherlands.
Peter van der MeerDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Tibor V VargaGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-214 28, Malmö, Sweden.
Niek VerweijDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Henry VölzkeDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany.
Nicholas J WarehamMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, CB2 0QQ, UK.
Helen R WarrenClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Stefan WeissDZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, University Medicine, Greifswald, Germany.
Leah WetherillDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Hanieh YaghootkarGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Ersin YavasDepartment of Neuroscience, Psychology and Behaviour, University of Leicester, Leicester, UK.
Yu JiangInstitute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
Fang ChenInstitute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA.
Xiaowei ZhanDepartment of Clinical Science, Center for Genetics of Host Defense, University of Texas Southwestern, Dallas, TX, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK.
Wei ZhaoDepartment of Biostatistics and Epidemiology, University of Pennsylvania, Pennsylvania, PA, USA.
Wei ZhaoDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kaixin ZhouSchool of Medicine, University of Dundee, Dundee, UK.
Philippe AmouyelDepartment of Epidemiology and Public Health, Institut Pasteur de Lille, Lille, France.
Stefan BlankenbergDepartment of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.
Mark J CaulfieldClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Rajiv ChowdhuryMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Panos DeloukasWellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
Emanuele Di AngelantonioMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Marco FerrarioEPIMED Research Centre, Department of Medicine and Surgery, University of Insubria at Varese, Varese, Italy.
Jean FerrièresDepartment of Epidemiology, UMR 1027- INSERM, Toulouse University-CHU Toulouse, Toulouse, France.
Paul W FranksGenetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Skåne University Hospital, Lund University, SE-214 28, Malmö, Sweden.
Tim M FraylingGenetics of Complex Traits, University of Exeter Medical School, Exeter, UK.
Philippe FrossardCentre for Non-Communicable Diseases, Karachi, Pakistan.
Ian P HallDivision of Respiratory Medicine and NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
Caroline HaywardMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Jan-Håkan JanssonDepartment of Public Health and Clinical Medicine, Skellefteå Research Unit, Umeå University, Umeå, Sweden.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Frank KeeUKCRC Centre of Excellence for Public Health, Queens, University, Belfast, Belfast, UK.
Satu MännistöDepartment of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu, Estonia.
Patricia B MunroeClinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Børge Grønne NordestgaardDepartment of Clinical Biochemistry Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 74, DK-2730, Herlev, Denmark.
Colin N A PalmerMedical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Veikko SalomaaDepartment of Public Health Solutions, National Institute for Health and Welfare, FI-00271, Helsinki, Finland.
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Timothy SpectorDepartment of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK.
David Peter StrachanPopulation Health Research Institute, St George!s, University of London, London, SW17 0RE, UK.
Understanding Society Scientific Group, EPIC-CVD, GSCAN, Consortium for Genetics of Smoking Behaviour, CHD Exome+ consortium
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Eleftheria ZegginiWellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
Danish SaleheenMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Louise V WainDepartment of Health Sciences, University of Leicester, Leicester, UK.
Goncalo R AbecasisDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
John DaneshMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Martin D Tobin *Department of Health Sciences, University of Leicester, Leicester, UK.
Scott Vrieze *Department of Psychology, University of Minnesota, Minneapolis, MN, USA.
Dajiang J Liu *Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA. dxl46@psu.edu.
Joanna M M Howson *MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. jmmh2@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0001-7618-0050
University of Cambridge · GBUniversity of Michigan · USUniversity of Leicester · GBQueen Mary University of London · GBWashington University in St. Louis · USUniversity of Minnesota · USAmsterdam Neuroscience · NLFinnish Institute for Health and Welfare · FIUniversity of Edinburgh · GBUniversity of Exeter · GBUniversity of Helsinki · FIUniversity of Washington · USCenter for Non-Communicable Diseases · PKHelmholtz Zentrum München · DEIcahn School of Medicine at Mount Sinai · USImperial College Healthcare NHS Trust · GBImperial College London · GBIndiana University School of MedicineMontreal Heart Institute · CAPenn State Milton S. Hershey Medical Center · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Creating a National Resource for Genetic Research in Behavioral & Health SciencesRC2AG036495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2009 to 2010
$7.4M
Identifying Genes for Type 2 Diabetes:FUSIONR01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2003 to 2025
$6.7M
Expanding a National Resource for Genetic Research in Behavioral & Health ScienceRC4AG039029 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2010 to 2010
$6.0M
Gene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9M
Aging-related Traits and Disease Risk Factors in a Sardinian Population CohortZIAAG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI GOROSPE, MYRIAM · 2009 to 2021
$5.7M
Genetic Mechanisms of Arteriosclerosis in Hypertensive SibshipsR01HL119443 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARDIA, SHARON L · 2014 to 2017
$2.1M
Method to Enhance the Rare Variant Genetic Architecture Analysis in Meta-AnalysesR01HG008983 · NHGRI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LIU, DAJIANG · 2016 to 2019
$1.6M
Tools for integrative genomics and disease association study for the X chromosomeR01GM126479 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LIU, DAJIANG · 2018 to 2021
$1.2M
Methods to Unveil the Genetic Architecture for Nicotine Dependence via NGS dataR21DA040177 · NIDA · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LIU, DAJIANG · 2015 to 2016
$447k
ARACHIDONATE METABOLISM IN GLOMERULONEPHRITIS/VASCULITISK08HL001313 · NHLBI · WASHINGTON UNIVERSITY · PI LEFKOWITH, JAMES B · 1985 to 1988
–
Biotechnology and Biological Sciences Research Council BB/F019394/1British Heart Foundation PG/02/128British Heart Foundation RE/13/5/30177British Heart Foundation RG/07/005/23633British Heart Foundation RG/08/014/24067British Heart Foundation RG/13/13/30194British Heart Foundation RG/14/5/30893British Heart Foundation SP/04/002British Heart Foundation SP/08/005/25115British Heart Foundation SP/09/002Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 16561Cancer Research UK 20861Cancer Research UK C490/A16561Chief Scientist Office CZD/16/6Chief Scientist Office ETM/55Department of Health 16/136/68Department of Health BTRU-2014-10024Department of Health HPRU-2012-10141Department of Health RP-PG-0407-10371European Research Council 268834Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G0800270Medical Research Council G1000861Medical Research Council G1001799Medical Research Council G9521010DMedical Research Council MC_PC_12010Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MC_U106179471Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12015/1Medical Research Council MR/K023241/1Medical Research Council MR/K026992/1Medical Research Council MR/L003120/1Medical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1Medical Research Council MR/M013111/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2Medical Research Council MR/N011317/1Medical Research Council MR/R023484/1Medical Research Council MR/S003746/1Medical Research Council MR/S003762/1NHGRI NIH HHS R01 HG008983NHLBI NIH HHS R01 HL119443NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740NICHD NIH HHS R01 HD057194NIDA NIH HHS R21 DA040177NIDDK NIH HHS R01 DK062370NIDDK NIH HHS U01 DK062370NIGMS NIH HHS R01 GM126479Wellcome Trust 083948Wellcome Trust 084723/Z/08/ZWellcome Trust 085475Wellcome Trust 090532Wellcome Trust 098381Wellcome Trust 104036/Z/14/ZWellcome Trust 212945/Z/18/ZWellcome Trust WT098051
6 · The paper itself

Abstract

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer, common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have previously been associated with smoking behaviour-related traits. We tested up to 235,116 single nucleotide variants (SNVs) on the exome-array for association with smoking initiation, cigarettes per day, pack-years, and smoking cessation in a fixed effects meta-analysis of up to 61 studies (up to 346,813 participants). In a subset of 112,811 participants, a further one million SNVs were also genotyped and tested for association with the four smoking behaviour traits. SNV-trait associations with P < 5 × 10

Indexed as

Genetic LociBiological Specimen BanksDatabases, FactualEuropeExomeFemaleHumansMalePolymorphism, Single NucleotideSmokingUnited Kingdom

Identifiers

PMID30617275
PMCPMC7515840
OpenAlexW2906948958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.