SynthesisNature genetics2019
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Erratum issuedOpen access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1,497 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,497citing papers in PubMed, 5 pooled it
250.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1,497 citing papers in PubMed, 5 syntheses or guidelines pooled it, 2,471 citations in OpenAlex.
- Consensus meta-analysis of genome-wide association studies for Alzheimer's disease and related dementias.Nature genetics · 2026Pooled it
- Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.PLoS genetics · 2026Pooled it
- A meta-analysis of single-nucleus expression quantitative trait loci linking genetic risk to brain disorders.Nature genetics · 2026Pooled it
- A Multi-Ancestry GWAS Meta-Analysis Integrated with In-Depth Silico, Systems Biology, and Pharmacogenomics Approaches on Alzheimer's Disease Among 1,198,689 Subjects.Journal of molecular neuroscience : MN · 2025Pooled it
- Evidence for Causal Links Between Known Modifiable Risk Factors and Dementia: A Systematic Review of Mendelian Randomisation Studies.European journal of neurology · 2025Pooled it
- Genetic Variation in Response to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND): A Randomized Controlled Trial.Nutrients · 2026Trial
- Insulin Resistance and Blood Pressure Control on Cognitive Outcomes.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular alterations in the basolateral amygdala of older Veterans.Neurobiology of aging · 2026Article
- Alzheimer's disease target and drug discovery by leveraging multiomics and electronic health data.Nature neuroscience · 2026Article
- Potential roles of aspartic acid D-isomerization in proteins implicated in the pathogenesis of Alzheimer's disease.Neural regeneration research · 2026Article
- Predicted brain-regional gene expression patterns in individuals living with Alzheimer's disease.Neurobiology of aging · 2026Article
- Role of Polygenic Risk Scores in Predicting Cognitive Functioning after Mild Traumatic Brain Injury: A TRACK-TBI Study.Journal of neurotrauma · 2026Article
- Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn's disease.Nature genetics · 2026Article
- Genetic links between multimorbidity and human aging.GeroScience · 2026Article
- Integrative prediction of Alzheimer's disease and related dementias using multi-omics aging clocks and genetic data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- APOE-stratified genome-wide association analyses provide insights into the genetic etiology of Alzheimers's disease.Nature genetics · 2026Article
- Convergent mitochondrial impairment and apoptosis driven by simultaneous down-regulation of multiple genes at 11p11.2 in Alzheimer's disease.Molecular psychiatry · 2026Article
- Single-cell profiling and genetic regulation of alternative polyadenylation in the human brain.Nature genetics · 2026Article
- A new era of genome-wide association studies in the field of Alzheimer's disease and overlapping co-pathologies: lessons learned from a neuropathology-centered approach.Acta neuropathologica · 2026Review
- Artificial Intelligence for Alzheimer's Disease Diagnosis: From Traditional Machine Learning to Large Language Models.Biosensors · 2026Review
1,437 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
53 authors at 19 institutions in 7 countries.
Iris E Jansen *Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1901-8131
Jeanne E Savage *Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-2034-8341
Kyoko WatanabeDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.
Julien BryoisDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Dylan M WilliamsDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Stacy SteinbergdeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7726-5152
Julia SealockInterdisciplinary Graduate Program, Vanderbilt University, Nashville, TN, USA.
Ida K KarlssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-2452-1500
Lavinia AthanasiuNORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Nicola VoyleInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Petroula ProitsiInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-2553-6974
Aree WitoelarNORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sven StringerDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3115-8532
Dag AarslandInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Ina S AlmdahlDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.ORCID http://orcid.org/0000-0001-6070-4921
Fred AndersenDepartment of Community Medicine, University of Tromsø, Tromsø, Norway.
Sverre BerghNorwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Francesco BettellaNORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sigurbjorn BjornssonDepartment of Geriatric Medicine, Landspitali University Hospital, Reykjavik, Iceland.
Anne BrækhusNorwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Geir BråthenDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-3224-7983
Christiaan de LeeuwDepartment of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-1076-9828
Rahul S DesikanNeuroradiology Section, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Srdjan DjurovicNORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-8140-8061
Logan DumitrescuVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.
Tormod FladbyDepartment of Neurology, Akershus University Hospital, Lørenskog, Norway.
Timothy J HohmanVanderbilt Memory & Alzheimer's Center, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-3377-7014
Palmi V JonssonDepartment of Geriatric Medicine, Landspitali University Hospital, Reykjavik, Iceland.
Steven J KiddleMRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-4350-7437
Arvid RongveDepartment of Research and Innovation, Helse Fonna, Haugesund, Norway.
Ingvild SaltvedtDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Sigrid B SandoDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Geir SelbækNorwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Maryam ShoaiDepartment of Neurodegenerative Disorders, Institute of Neurology, UCL, London, UK.
Nathan G SkeneLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6807-3180
Jon SnaedalDepartment of Geriatric Medicine, Landspitali University Hospital, Reykjavik, Iceland.
Eystein StordalDepartment of Psychiatry, Namsos Hospital, Namsos, Norway.ORCID http://orcid.org/0000-0002-2443-7923
Ingun D UlsteinMemory Clinic, Geriatric Department, Oslo University Hospital, Oslo, Norway.
Yunpeng WangNORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Linda R WhiteDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
John HardyDepartment of Neurodegenerative Disorders, Institute of Neurology, UCL, London, UK.
Jens Hjerling-LefflerLaboratory of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-4539-1776
Patrick F SullivanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Wiesje M van der FlierAlzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
Richard DobsonInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-4224-9245
Lea K DavisVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
Hreinn StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.
Kari StefanssondeCODE Genetics/Amgen, Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1676-864X
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Stephan Ripke *Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Ole A Andreassen *NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-4461-3568
Danielle Posthuma *Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University, Amsterdam, the Netherlands. d.posthuma@vu.nl.ORCID http://orcid.org/0000-0001-7582-2365
Amsterdam Neuroscience · NLKarolinska Institutet · SEUniversity of Oslo · NONorwegian University of Science and Technology · NOOslo University Hospital · NOdeCODE Genetics (Iceland) · ISKing's College London · GBReykjavík University · ISVanderbilt University Medical Center · USUniversity College London · GBBroad Institute · USFonna Hospital TrustInnlandet Hospital Trust · NOUiT The Arctic University of Norway · NOUniversity of California, San Francisco · USUniversity of Cambridge · GBUniversity of London · GBUniversity of North Carolina at Chapel Hill · USVanderbilt University · US
Funding
Genetic Drivers of Resilience to Alzheimer's DiseaseR01AG059716 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HOHMAN, TIMOTHY J · 2018 to 2022
$4.4MTraining Program on Genetic Variation and Human PhenotypesT32GM080178 · NIGMS · VANDERBILT UNIVERSITY · PI COX, NANCY J, SAMUELS, DAVID C · 2007 to 2021
$3.1M3/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109536 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CHARNEY, ALEXANDER W, HUCKINS, LAURA MARIANNE · 2016 to 2020
$2.7MGenetic Resilience to the Clinical Manifestation of DementiaK01AG049164 · NIA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HOHMAN, TIMOTHY J · 2016 to 2020
$595kEPA EP-C-14-005Medical Research Council MC_PC_17214Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/P021573/1NIA NIH HHS K01 AG049164NIA NIH HHS R01 AG059716NIGMS NIH HHS T32 GM080178NIMH NIH HHS U01 MH109536
Abstract
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, showed strong genetic correlation with AD (r
Indexed as
AdultAlzheimer DiseaseCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociRiskYoung Adult
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.