Evidence map›Paper›PMID 30617225›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Neutrophil Cathepsin G Regulates Dendritic Cell Production of IL-12 during Development of CD4 T Cell Responses to Antigens in the Skin.

Danielle D Kish, Susie Min, Nina Dvorina, William M Baldwin, Stephen A Stohlman, Robert L Fairchild

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Innate Immune Mechanisms in Contact Dermatitis.Handbook of experimental pharmacology · 2022
    Article
  6. Contact dermatitis.Nature reviews. Disease primers · 2021
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Danielle D KishLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Susie MinLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Nina DvorinaLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
William M BaldwinLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Stephen A StohlmanLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Robert L FairchildLerner Research Institute, Cleveland Clinic, Cleveland, OH 44195 fairchr@ccf.org.ORCID 0000-0002-7107-5259
Cleveland Clinic Lerner College of Medicine · US

Funding

POSTTRANSPLANT INFLAMMATORY RESPONSER01AI040459 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI Robert L Fairchild · 1997 to 2026
$9.4M
Innate Mechanisms Regulating CD8+ T Cell ImmunityR01AI045888 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI FAIRCHILD, ROBERT L · 1999 to 2010
$2.4M
NIAID NIH HHS R01 AI040459NIAID NIH HHS R01 AI045888
6 · The paper itself

Abstract

Contact hypersensitivity (CHS) is a CD8 T cell-mediated response to hapten skin sensitization and challenge. Sensitization of wild-type (WT) mice induces hapten-reactive effector CD8 T cells producing IFN-γ and IL-17- and IL-4-producing CD4 T cells that cannot mediate CHS. Although CXCR2-dependent Ly6G

Indexed as

AnimalsCathepsin GCD4-Positive T-LymphocytesDendritic CellsDermatitis, ContactFemaleHaptensInterleukin-12MiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutNeutrophilsReceptors, Interleukin-8BSkinCathepsin GHaptensInterleukin-12Receptors, Interleukin-8B

Identifiers

PMID30617225
PMCPMC6363895
OpenAlexW2908249472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.