Evidence map›Paper›PMID 30617212›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development.

Xiaxia Xu, Mattia Chini, Sebastian H Bitzenhofer, Ileana L Hanganu-Opatz

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-ChallengedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  2. Development of Prefrontal Circuits and Cognitive Abilities.Cold Spring Harbor perspectives in biology · 2024
    Review
  3. Article
  4. Gamma oscillations provide insights into cortical circuit development.Pflugers Archiv : European journal of physiology · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Neuronal oscillations: early biomarkers of psychiatric disease?Frontiers in behavioral neuroscience · 2022
    Review
  11. Article
  12. The Logic of Developing Neocortical Circuits in Health and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  13. Article
  14. Self and the Brain. The Immune Metaphor.Frontiers in psychiatry · 2020
    Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Xiaxia XuDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Mattia ChiniDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Sebastian H BitzenhoferDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0003-0736-6251
Ileana L Hanganu-OpatzDevelopmental Neurophysiology, Institute of Neuroanatomy, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany hangop@zmnh.uni-hamburg.de.ORCID 0000-0002-4787-1765
Universität Hamburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compromised brain development has been hypothesized to account for mental illness. This concept was underpinned by the function of the molecule disrupted-in-schizophrenia 1 (DISC1), which represents an intracellular hub of developmental processes and has been related to cognitive dysfunction in psychiatric disorders. Mice with whole-brain DISC1 knock-down show impaired prefrontal-hippocampal function and cognitive abilities throughout development and at adulthood, especially when combined with early environmental stressors, such as maternal immune activation (MIA). However, the contribution of abnormal DISC1-driven maturation of either prefrontal cortex (PFC) or hippocampus (HP) to these deficits is still unknown. Here, we use

Indexed as

AnimalsBehavior, AnimalCognitive DysfunctionExploratory BehaviorFemaleGene Knockdown TechniquesHippocampusMiceMice, Inbred C57BLNerve Tissue ProteinsNeural PathwaysPrefrontal CortexPregnancyPrenatal Exposure Delayed EffectsPyramidal CellsRecognition, PsychologyDisc1 protein, mouseNerve Tissue ProteinsdevelopmentDISC1network oscillationsprefrontal–hippocampal communicationprefrontal maturation

Identifiers

PMID30617212
PMCPMC6381232
OpenAlexW2908296149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.