ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Transient Knock-Down of Prefrontal DISC1 in Immune-Challenged Mice Causes Abnormal Long-Range Coupling and Cognitive Dysfunction throughout Development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-ChallengedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Development of Prefrontal Circuits and Cognitive Abilities.Cold Spring Harbor perspectives in biology · 2024Review
- A developmental increase of inhibition promotes the emergence of hippocampal ripples.Nature communications · 2024Article
- Gamma oscillations provide insights into cortical circuit development.Pflugers Archiv : European journal of physiology · 2023Review
- Investigating behavioral phenotypes related to autism spectrum disorder in a gene-environment interaction model ofFrontiers in neuroscience · 2023Article
- Electroacupuncture improves cognitive impairment in diabetic cognitive dysfunction rats by regulating the mitochondrial autophagy pathway.The journal of physiological sciences : JPS · 2022Article
- Article
- Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice.Nature communications · 2022Article
- Sparser and Less Efficient Hippocampal-Prefrontal Projections account for Developmental Network Dysfunction in a Model of Psychiatric Risk Mediated by Gene-Environment Interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neuronal oscillations: early biomarkers of psychiatric disease?Frontiers in behavioral neuroscience · 2022Review
- Developmental decrease of entorhinal-hippocampal communication in immune-challenged DISC1 knockdown mice.Nature communications · 2021Article
- The Logic of Developing Neocortical Circuits in Health and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Knock-Down of Hippocampal DISC1 in Immune-Challenged Mice Impairs the Prefrontal-Hippocampal Coupling and the Cognitive Performance Throughout Development.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Self and the Brain. The Immune Metaphor.Frontiers in psychiatry · 2020Article
- Shifting Developmental Trajectories During Critical Periods of Brain Formation.Frontiers in cellular neuroscience · 2020Review
- Developmental dysfunction of prefrontal-hippocampal networks in mouse models of mental illness.The European journal of neuroscience · 2019Article
- The transcriptome landscape associated with Disrupted-in-Schizophrenia-1 locus impairment in early development and adulthood.Schizophrenia research · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compromised brain development has been hypothesized to account for mental illness. This concept was underpinned by the function of the molecule disrupted-in-schizophrenia 1 (DISC1), which represents an intracellular hub of developmental processes and has been related to cognitive dysfunction in psychiatric disorders. Mice with whole-brain DISC1 knock-down show impaired prefrontal-hippocampal function and cognitive abilities throughout development and at adulthood, especially when combined with early environmental stressors, such as maternal immune activation (MIA). However, the contribution of abnormal DISC1-driven maturation of either prefrontal cortex (PFC) or hippocampus (HP) to these deficits is still unknown. Here, we use
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.