Evidence map›Paper›PMID 30617211›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Stroke Accelerates and Uncouples Intrinsic and Synaptic Excitability Maturation of Mouse Hippocampal DCX

Mihai Ceanga, Silke Keiner, Benedikt Grünewald, Holger Haselmann, Christiane Frahm, Sebastien Couillard-Després, Otto W Witte, Christoph Redecker, Christian Geis, Albrecht Kunze

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  7. Article
  8. Review
  9. Article
  10. Post-stroke Neurogenesis: Friend or Foe?Frontiers in cell and developmental biology · 2021
    Review
  11. Article
  12. Review
  13. Stroke Primes New Hippocampal Neurons for Hyperexcitability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Mihai CeangaHans Berger Department of Neurology.
Silke KeinerHans Berger Department of Neurology.ORCID 0000-0001-5225-9565
Benedikt GrünewaldHans Berger Department of Neurology.ORCID 0000-0001-5302-6130
Holger HaselmannHans Berger Department of Neurology.
Christiane FrahmHans Berger Department of Neurology.
Sebastien Couillard-DesprésInstitute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria.ORCID 0000-0002-8486-6412
Otto W WitteHans Berger Department of Neurology.ORCID 0000-0003-2101-4105
Christoph RedeckerHans Berger Department of Neurology.
Christian GeisHans Berger Department of Neurology.ORCID 0000-0002-9859-581X
Albrecht KunzeHans Berger Department of Neurology, albrecht.kunze@med.uni-jena.de.ORCID 0000-0002-3564-6237
Berger (Canada) · CAJena University Hospital · DEParacelsus Medical University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke robustly stimulates adult neurogenesis in the hippocampal dentate gyrus. It is currently unknown whether this process induces beneficial or maladaptive effects, but morphological and behavioral studies have reported aberrant neurogenesis and impaired hippocampal-dependent memory following stroke. However, the intrinsic function and network incorporation of adult-born granule cells (ABGCs) after ischemia is unclear. Using patch-clamp electrophysiology, we evaluated doublecortin-positive (DCX

Indexed as

NeurogenesisSynaptic PotentialsAnimalsDentate GyrusDoublecortin Domain ProteinsDoublecortin ProteinFemaleGlutamic AcidInfarction, Middle Cerebral ArteryMaleMiceMicrotubule-Associated ProteinsNeuronsNeuropeptidesDcx protein, mouseDoublecortin Domain ProteinsDoublecortin ProteinGlutamic AcidMicrotubule-Associated ProteinsNeuropeptidesaberrant integrationadult neurogenesisdoublecortinhyperexcitabilitystrokeuncoupled maturation

Identifiers

PMID30617211
PMCPMC6391573
OpenAlexW2907790393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.