Evidence map›Paper›PMID 30617203›Full record

ArticleInfection and immunity2019

Indole Inhibits ToxR Regulon Expression in

Mondraya F Howard, X Renee Bina, James E Bina

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Indole decreases the virulence of enterotoxigenic Escherichia coli.World journal of microbiology & biotechnology · 2026
    Article
  3. Article
  4. Article
  5. Microorganisms · 2026
    Article
  6. Strain-dependentFrontiers in microbiology · 2026
    Article
  7. mBio · 2024
    Article
  8. Article
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mondraya F HowardDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
X Renee BinaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
James E BinaDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA jbina@pitt.edu.
University of Pittsburgh · US

Funding

Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
Environmental adaptation by Vibrio choleraeR01AI132460 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAMES Edward BINA · 2018 to 2026
$3.2M
Environmental adaptation by Vibrio choleraeR56AI132460 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BINA, JAMES EDWARD · 2022 to 2022
$467k
The role of ToxR signal transduction in Vibrio cholerae pathogenesisF31AI129381 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD, MONDRAYA · 2017 to 2018
$81k
NIAID NIH HHS F31 AI129381NIAID NIH HHS R01 AI132460NIAID NIH HHS R56 AI132460NIAID NIH HHS T32 AI049820
6 · The paper itself

Abstract

Indole is a degradation product of tryptophan that functions as a signaling molecule in many bacteria. This includes

Indexed as

Adhesins, BacterialBacterial ProteinsCholera ToxinDNA-Binding ProteinsFimbriae ProteinsGene Expression Regulation, BacterialIndolesMutationRegulonTranscription FactorsVibrio choleraeAdhesins, BacterialBacterial ProteinsCholera ToxinDNA-Binding ProteinsFimbriae ProteinsindoleIndolesOmpU protein, Vibrio choleraeTcpA protein, Vibrio choleraetoxR protein, Vibrio choleraeTranscription Factorsbiofilmscholeraindolevirulence regulation

Identifiers

PMID30617203
PMCPMC6386550
OpenAlexW2908782516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.