Evidence map›Paper›PMID 30617195›Full record

ArticleBlood2019

Anti-human CD117 antibody-mediated bone marrow niche clearance in nonhuman primates and humanized NSG mice.

Hye-Sook Kwon, Aaron C Logan, Akanksha Chhabra, Wendy W Pang, Agnieszka Czechowicz, Keri Tate, Alan Le, Jessica Poyser, Roger Hollis, Benjamin V Kelly and 4 more

Open access · bronzeAbstract readLetter
In one paragraph

Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Restoration of the immune system with base editing and non-genotoxic conditioning in a Rag2 point-mutant mouse model.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. To c or not to c-KIT?: High toxicity and modest efficacy in CD117-directed CAR T cell therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Hye-Sook KwonDivision of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA.
Aaron C LoganDivision of Malignant Hematology and Blood and Marrow Transplantation, Department of Medicine, University of California, San Francisco, San Francisco, CA.
Akanksha ChhabraDivision of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA.
Wendy W PangDivision of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA.
Agnieszka CzechowiczDivision of Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics.
Keri TateStanford Laboratory for Cell and Gene Medicine, Stanford University, Palo Alto, CA.
Alan LeDivision of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA.
Jessica PoyserDivision of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA.
Roger HollisDepartment of Microbiology, Immunology, and Molecular Genetics.
Benjamin V KellyDepartment of Orthopaedic Surgery, David Geffen School of Medicine, and.
Donald B KohnDepartment of Microbiology, Immunology, and Molecular Genetics.
Irving L WeissmanDepartment of Pathology, and.
Susan S ProhaskaDivision of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA.
Judith A ShizuruDivision of Blood and Marrow Transplantation, Department of Medicine, School of Medicine, Stanford University, Stanford, CA.
Stanford University · USStanford Cancer InstituteLaboratory of Molecular Genetics · PLUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

TUMOR SPECIFIC CYTOTOXIC T-LYMPHOCYTES IN BONE MARROW TRANSPLANTATIONP01CA049605 · NCI · STANFORD UNIVERSITY · PI David B. Miklos · 1989 to 2026
$73.3M
Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
HSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionR01CA086065 · NCI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 2000 to 2017
$6.9M
HOMING RECEPTOR DETERMINANTS ON HSCR01HL058770 · NHLBI · STANFORD UNIVERSITY · PI WEISSMAN, IRVING L. · 1998 to 2013
$3.9M
NCI NIH HHS P01 CA049605NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA086065NHLBI NIH HHS R01 HL058770
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntibodies, MonoclonalBone MarrowHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHeterograftsHumansMacaca fascicularisMiceProto-Oncogene Proteins c-kitStem Cell NicheAntibodies, MonoclonalKIT protein, humanProto-Oncogene Proteins c-kit

Identifiers

PMID30617195
PMCPMC6509543
OpenAlexW2910465831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.