ArticleBlood2019
Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma.
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Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 1 pooled it
14.3field-weighted citation impact, top 1% of its field
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Who cites it
150 citing papers in PubMed, 1 synthesis or guideline pooled it, 273 citations in OpenAlex.
- A genetic profiling guideline to support diagnosis and clinical management of lymphomas.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Guideline
- Burkitt lymphoma: current understanding, unmet needs, and research directions.Blood advances · 2026Review
- Article
- Mechanistic interactions between Plasmodium falciparum and Epstein-Barr virus in endemic Burkitt Lymphoma pathogenesis: a narrative review (2010-2026).Infectious agents and cancer · 2026Review
- Review
- RFX7 is a tumor suppressor that restricts MYC function and B cell activation.Nature immunology · 2026Article
- Regulatory factor X 7 limits Myc activity during B cell activation and suppresses Myc-dependent lymphomagenesis.Nature immunology · 2026Article
- Single-cell whole-genome sequencing reveals convergent evolution in Burkitt lymphoma.Nature communications · 2026Article
- Access to diagnosis using liquid biopsy (ADLiB): Identifying lymphoma in a tuberculosis-endemic setting.HemaSphere · 2026Article
- Liquid biopsy for the diagnosis of EBV-positive Burkitt's lymphoma in endemic areas.Nature medicine · 2026Article
- SFK Inhibition Suppresses EBV-Encoded BART miRNAs and Induces Apoptosis in EBV-Positive Gastric Epithelial Cells.Cancers · 2026Article
- Epstein-Barr virus-associated lymphoma: current understanding and treatment strategies.Blood research · 2026Review
- Burkitt Lymphoma-A Guide to Biological Features, Diagnosis and Differential Diagnosis.Cancers · 2026Review
- miRNA profiling in pediatric and young adult Burkitt leukemia and lymphoma.Virchows Archiv : an international journal of pathology · 2026Article
- Case Report: Glofitamab in the treatment of a patient with central nervous system-involved Burkitt lymphoma.Frontiers in oncology · 2026Article
- Hit-and-run hypothesis: revisiting the impact of EBV in malignancies.Frontiers in immunology · 2026Review
- Higher chemical complementarity of EBV epitopes and IGH CDR3s correlates with better outcomes for lymphoma and ovarian cancer.Cancer causes & control : CCC · 2025Article
- Epstein-Barr virus infection shapes the genetic, transcriptomic, and immune microenvironment landscape of Burkitt lymphoma.Infectious agents and cancer · 2025Article
- Proteomic analysis of Burkitt lymphoma tissues: insights into the impact of age and EBV infection on protein expression and molecular characteristics.Discover oncology · 2025Article
- High-grade B-cell lymphoma, not otherwise specified: an LLMPP study.Blood advances · 2025Article
90 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
53 authors at 17 institutions in 4 countries.
Bruno M GrandeDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0002-4621-1589
Daniela S GerhardOffice of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Aixiang JiangDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Nicholas B GrinerOffice of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Jeremy S AbramsonCenter for Lymphoma, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Thomas B AlexanderDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN.
Hilary AllenNationwide Children's Hospital, Columbus, OH.
Leona W AyersDepartment of Pathology, The Ohio State University, Columbus, OH.
Jeffrey M BethonyGeorge Washington University, Washington, DC.
Kishor BhatiaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.
Jay BowenNationwide Children's Hospital, Columbus, OH.
Corey CasperInfectious Disease Research Institute, Seattle, WA.ORCID 0000-0002-3609-661X
John Kim ChoiDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN.
Luka CulibrkCanada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.
Tanja M DavidsenCancer Informatics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Maureen A DyerClinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD.
Julie M Gastier-FosterNationwide Children's Hospital, Columbus, OH.
Patee GesuwanCancer Informatics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Timothy C GreinerDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE.
Thomas G GrossCenter for Global Health, National Cancer Institute, National Institutes of Health, Rockville, MD.
Benjamin HanfNationwide Children's Hospital, Columbus, OH.
Nancy Lee HarrisDepartment of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Yiwen HeCancer Informatics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
John D IrvinFoundation for Burkitt Lymphoma Research, Geneva, Switzerland.
Elaine S JaffeLaboratory of Pathology, Clinical Center, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Steven J M JonesDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Patrick KerchanEMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
Nicole KnoetzeDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0001-8712-1566
Fabio E LealPrograma de Oncovirologia, Instituto Nacional de Câncer José de Alencar, Rio de Janeiro, Brazil.
Tara M LichtenbergNationwide Children's Hospital, Columbus, OH.
Yussanne MaCanada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.
Jean Paul MartinFoundation for Burkitt Lymphoma Research, Geneva, Switzerland.
Marie-Reine MartinFoundation for Burkitt Lymphoma Research, Geneva, Switzerland.
Sam M MbulaiteyeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD.ORCID 0000-0002-8273-9831
Charles G MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-1871-1850
Andrew J MungallCanada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.ORCID 0000-0002-0905-2742
Constance NamirembeUganda Cancer Institute, Kampala, Uganda.
Karen NovikCanada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.
Ariela NoyMemorial Sloan Kettering Cancer Center, New York, NY.
Martin D OgwangEMBLEM Study, St. Mary's Hospital Lacor, Gulu, Uganda.
Abraham OmodingUganda Cancer Institute, Kampala, Uganda.
Jackson OremUganda Cancer Institute, Kampala, Uganda.
Steven J ReynoldsDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; and.
Christopher K RushtonDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
John T SandlundDepartment of Oncology, St. Jude Children's Research Hospital, Memphis, TN.
Roland SchmitzLymphoid Malignancies Branch, Center for Cancer Research and.
Cynthia TaylorNationwide Children's Hospital, Columbus, OH.
Wyndham H WilsonLymphoid Malignancies Branch, Center for Cancer Research and.
George W WrightBiometric Research Program, Division of Cancer Diagnosis and Treatment, National Cancer Institute, National Institutes of Health, Rockville, MD.
Eric Y ZhaoCanada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.
Marco A MarraCanada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada.ORCID 0000-0001-7146-7175
Ryan D MorinDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0003-2932-7800
Louis M StaudtLymphoid Malignancies Branch, Center for Cancer Research and.
National Institutes of Health · USCanada's Michael Smith Genome Sciences Centre · CANationwide Children's Hospital · USSimon Fraser University · CASt. Jude Children's Research Hospital · USCenter for Cancer Research · USUganda Cancer Institute · UGHarvard University · USAfrican Field Epidemiology Network · UGFrederick National Laboratory for Cancer Research · USGeorge Washington University · USInfectious Disease Research Institute · USInstituto Nacional de Câncer - INCA · BRMemorial Sloan Kettering Cancer Center · USSt. Mary's Hospital Lacor · UGThe Ohio State University · USUniversity of Nebraska Medical Center · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MViral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MTranslational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3MUniversity of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9MInternational Center for Excellence in Research (ICER) in Uganda: Impact of ARVsZIAAI001040 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REYNOLDS, STEVEN · 2009 to 2025
$23.5MMolecular diagnosis and outcome prediction in lymphomaZIABC011006 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI STAUDT, LOUIS · 2009 to 2025
$21.0MTranslating genomic discoveries to improved outcomes for high risk acute leukemiaR35CA197695 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Charles G Mullighan · 2017 to 2026
$11.4MCCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS HHSN261201100007INCI NIH HHS HHSN261201100063CNCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016058NCI NIH HHS P30 CA021765NCI NIH HHS R35 CA197695NHLBI NIH HHS HHSN261201100007CNIAID NIH HHS P30 AI027757
Abstract
Although generally curable with intensive chemotherapy in resource-rich settings, Burkitt lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa. Epstein-Barr virus (EBV) positivity is a feature in more than 90% of cases in malaria-endemic regions, and up to 30% elsewhere. However, the molecular features of BL have not been comprehensively evaluated when taking into account tumor EBV status or geographic origin. Through an integrative analysis of whole-genome and transcriptome data, we show a striking genome-wide increase in aberrant somatic hypermutation in EBV-positive tumors, supporting a link between EBV and activation-induced cytidine deaminase (AICDA) activity. In addition to identifying novel candidate BL genes such as
Indexed as
Genes, ImmunoglobulinGenome, HumanMutationTranscriptomeAdolescentAdultAICDA (Activation-Induced Cytidine Deaminase)Biomarkers, TumorBurkitt LymphomaChildChild, PreschoolCohort StudiesCytidine DeaminaseEpstein-Barr Virus InfectionsFemaleFollow-Up StudiesAICDA (Activation-Induced Cytidine Deaminase)Biomarkers, TumorCytidine Deaminase
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.