ArticleMolecular & cellular proteomics : MCP2019
In-depth Proteome of the Hypopharyngeal Glands of Honeybee Workers Reveals Highly Activated Protein and Energy Metabolism in Priming the Secretion of Royal Jelly.
Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 59 citations in OpenAlex.
- Organic Acid Supplementation in Worker Honeybees (Insects · 2025Review
- Selection and validation of RT-qPCR reference genes for multi-tissue gene expression normalization in two honeybee subspecies across post-emergence developmental stages.BMC genomics · 2025Article
- Mechanistic exploration of royal jelly production in caged honey bees (Apis mellifera).Scientific reports · 2024Article
- Article
- Article
- Discovery of SNP Molecular Markers and Candidate Genes Associated with Sacbrood Virus Resistance inInternational journal of molecular sciences · 2023Article
- Dnmt1a is essential for gene body methylation and the regulation of the zygotic genome in a wasp.PLoS genetics · 2022Article
- Genetic Drift and Purifying Selection Shaped Mitochondrial Genome Variation in the High Royal Jelly-Producing Honeybee Strain (Frontiers in genetics · 2022Article
- Evaluation of queen cell acceptance and royal jelly production between hygienic and non-hygienic honey bee (Apis mellifera) colonies.PloS one · 2022Article
- Effect of queen cell numbers on royal jelly production and quality.Current research in food science · 2022Article
- Article
- High royal jelly production does not impact the gut microbiome of honey bees.Animal microbiome · 2021Article
- Age and Behavior-Dependent Differential miRNAs Expression in the Hypopharyngeal Glands of Honeybees (Insects · 2021Article
- Alternative therapies for dry eye disease.Current opinion in ophthalmology · 2021Review
- Queen cells acceptance rate and royal jelly production in worker honey bees of two Apis mellifera races.PloS one · 2021Article
- Characterization of the mitochondrial genome of a high royal jelly-producing honeybee strain (Mitochondrial DNA. Part B, Resources · 2021Article
- Functional and transcriptomic analyses of the NF-Y family provide insights into the defense mechanisms of honeybees under adverse circumstances.Cellular and molecular life sciences : CMLS · 2020Article
- Novel Insight Into the Development and Function of Hypopharyngeal Glands in Honey Bees.Frontiers in physiology · 2020Review
- The Emerging Proteomic Research Facilitates in-Depth Understanding of the Biology of Honeybees.International journal of molecular sciences · 2019Review
- The rise and fall of major royal jelly proteins during a honeybee (Ecology and evolution · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Royal jelly (RJ) is a secretion of the hypopharyngeal glands (HGs) of honeybee workers. High royal jelly producing bees (RJBs), a stock of honeybees selected from Italian bees (ITBs), have developed a stronger ability to produce RJ than ITBs. However, the mechanism underpinning the high RJ-producing performance in RJBs is still poorly understood. We have comprehensively characterized and compared the proteome across the life span of worker bees between the ITBs and RJBs. Our data uncover distinct molecular landscapes that regulate the gland ontogeny and activity corresponding with age-specific tasks. Nurse bees (NBs) have a well-developed acini morphology and cytoskeleton of secretory cells in HGs to prime the gland activities of RJ secretion. In RJB NBs, pathways involved in protein synthesis and energy metabolism are functionally induced to cement the enhanced RJ secretion compared with ITBs. In behavior-manipulated RJB NBs, the strongly expressed proteins implicated in protein synthesis and energy metabolism further demonstrate their critical roles in the regulation of RJ secretion. Our findings provide a novel understanding of the mechanism consolidating the high RJ-output in RJBs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.