Evidence map›Paper›PMID 30617147›Full record

ArticleJournal of lipid research2019

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking.

McKenna Feltes, Samantha Moores, Sarah E Gale, Kathiresan Krishnan, Laurel Mydock-McGrane, Douglas F Covey, Daniel S Ory, Jean E Schaffer

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Cholesterol binding to VCAM-1 promotes vascular inflammation.bioRxiv : the preprint server for biology · 2024
    Article
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

McKenna FeltesDepartments of Medicine Washington University School of Medicine, St. Louis, MO 63110.
Samantha MooresDepartments of Medicine Washington University School of Medicine, St. Louis, MO 63110.
Sarah E GaleDepartments of Medicine Washington University School of Medicine, St. Louis, MO 63110.
Kathiresan KrishnanDevelopmental Biology Washington University School of Medicine, St. Louis, MO 63110.
Laurel Mydock-McGraneDevelopmental Biology Washington University School of Medicine, St. Louis, MO 63110.
Douglas F CoveyDevelopmental Biology Washington University School of Medicine, St. Louis, MO 63110.
Daniel S OryDepartments of Medicine Washington University School of Medicine, St. Louis, MO 63110 dory@wustl.edu.
Jean E SchafferDepartments of Medicine Washington University School of Medicine, St. Louis, MO 63110.
Washington University in St. Louis · US

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
Post-lysosomal cholesterol trafficking networksR01HL067773 · NHLBI · WASHINGTON UNIVERSITY · PI SCHAFFER, JEAN E. · 2002 to 2021
$6.3M
Training in Integrative and Systems Biology of Cardiovascular DiseaseT32HL134635 · NHLBI · WASHINGTON UNIVERSITY · PI NERBONNE, JEANNE M. · 2017 to 2021
$1.8M
Post-lysosomal Cholesterol Trafficking: Elucidating protein networks using diazirine alkyne probesF31HL142167 · NHLBI · WASHINGTON UNIVERSITY · PI FELTES, MCKENNA RAE · 2018 to 2019
$55k
NHLBI NIH HHS F31 HL142167NHLBI NIH HHS R01 HL067773NHLBI NIH HHS T32 HL134635NIDDK NIH HHS P30 DK056341
6 · The paper itself

Abstract

Cholesterol is an essential structural component of cellular membranes and precursor molecule for oxysterol, bile acid, and hormone synthesis. The study of intracellular cholesterol trafficking pathways has been limited in part due to a lack of suitable cholesterol analogues. Herein, we developed three novel diazirine alkyne cholesterol probes: LKM38, KK174, and KK175. We evaluated these probes as well as a previously described diazirine alkyne cholesterol analogue,

Indexed as

AlkynesBiological TransportCell Line, TumorChemistry Techniques, SyntheticCholesterolDiazomethaneHomeostasisHumansIntracellular SpaceLipoproteinsLysosomesMolecular ProbesAlkynesCholesterolDiazomethaneLipoproteinsMolecular Probesbiorthogonal probeslipidslipoproteinsmetabolismregulation

Identifiers

PMID30617147
PMCPMC6399506
OpenAlexW2910563144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.