Evidence map›Paper›PMID 30617118›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2019

Influenza Virus-Specific Human Antibody Repertoire Studies.

James E Crowe

Abstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Unique structural solution from a VNature communications · 2021
    Article
  11. The Future of Blood Testing Is the Immunome.Frontiers in immunology · 2021
    Article
  12. Article
  13. The Plasticity of Newly Formed B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

James E CroweVanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232; james.crowe@vanderbilt.edu.ORCID 0000-0002-0049-1079

Funding

Structure based design of antibodies and vaccinesU19AI117905 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SCHIEF, WILLIAM R. · 2015 to 2019
$12.0M
NIAID NIH HHS HHSN272201400024CNIAID NIH HHS U19 AI117905
6 · The paper itself

Abstract

The diversity of Ag-specific adaptive receptors on the surface of B cells and in the population of secreted Abs is enormous, but increasingly, we are acquiring the technical capability to interrogate Ab repertoires in great detail. These Ab technologies have been especially pointed at understanding the complex issues of immunity to infection and disease caused by influenza virus, one of the most common and vexing medical problems in man. Influenza immunity is particularly interesting as a model system because the antigenic diversity of influenza strains and proteins is high and constantly evolving. Discovery of canonical features in the subset of the influenza repertoire response that is broadly reactive for diverse influenza strains has spurred the recent optimism for creating universal influenza vaccines. Using new technologies for sequencing Ab repertoires at great depth is helping us to understand the central features of influenza immunity.

Indexed as

Antibodies, ViralAntibody DiversityAntigenic VariationAntigens, ViralB-LymphocytesHumansInfluenza A virusInfluenza, HumanInfluenza VaccinesReceptors, Antigen, B-CellAntibodies, ViralAntigens, ViralInfluenza VaccinesReceptors, Antigen, B-Cell

Identifiers

PMID30617118
PMCPMC6327975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.