Evidence map›Paper›PMID 30617109›Full record

ArticleJournal of cell science2019

Akt and SGK protein kinases are required for efficient feeding by macropinocytosis.

Thomas D Williams, Sew-Yeu Peak-Chew, Peggy Paschke, Robert R Kay

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 36 citations in OpenAlex.

  1. Two endogenousProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Actin dynamics in protein homeostasis.Bioscience reports · 2022
    Review
  7. Article
  8. The Amoebal Model for Macropinocytosis.Sub-cellular biochemistry · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Article
  16. Article
  17. Interactome and F-Actin Interaction Analysis ofInternational journal of molecular sciences · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Thomas D WilliamsMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK thomasw@mrc-lmb.cam.ac.uk.ORCID 0000-0002-0479-5678
Sew-Yeu Peak-ChewMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
Peggy PaschkeMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.ORCID 0000-0002-6248-5678
Robert R KayMRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.
MRC Laboratory of Molecular Biology · GB

Funding

Medical Research Council MC_U105115237Medical Research Council U105115237
6 · The paper itself

Abstract

Macropinocytosis is an actin-driven process of large-scale and non-specific fluid uptake used for feeding by some cancer cells and the macropinocytosis model organism

Indexed as

DictyosteliumPinocytosisProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktProtozoan ProteinsPKBR-1 protein, DictyosteliumProtein Serine-Threonine KinasesProto-Oncogene Proteins c-aktProtozoan ProteinsAktDictyosteliumEndocytosisMacropinocytosisPhosphoinositide 3-kinasePI3KSGK

Identifiers

PMID30617109
PMCPMC6624135
OpenAlexW2908338174

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.