Evidence map›Paper›PMID 30617095›Full record

ArticleAntimicrobial agents and chemotherapy2019

Evolution of Daptomycin Resistance in Coagulase-Negative Staphylococci Involves Mutations of the Essential Two-Component Regulator WalKR.

Jhih-Hang Jiang, Carina Dexter, David R Cameron, Ian R Monk, Sarah L Baines, Iain J Abbott, Denis W Spelman, Xenia Kostoulias, Cara Nethercott, Benjamin P Howden and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Emerging microbes & infections · 2026
    Article
  2. Evaluation of Changes inOpen forum infectious diseases · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Molecular Characterization of Cefoxitin-Resistant Coagulase-Negative Staphylococci From Frequently Touched Surfaces of Hospital and Urban-Built Environments of Central India.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  8. Review
  9. PredictingmSystems · 2024
    Article
  10. Clinical microbiology reviews · 2024
    Review
  11. Article
  12. The Fusaric Acid Derivative qy17 InhibitsFrontiers in microbiology · 2022
    Article
  13. Review
  14. Virulence Factors in Coagulase-Negative Staphylococci.Pathogens (Basel, Switzerland) · 2021
    Review
  15. Comparative genomics ofMicrobial genomics · 2021
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Loss of daptomycin susceptibility in clinicalEvolution, medicine, and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Jhih-Hang Jiang *Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Carina Dexter *Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
David R CameronInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Ian R MonkDepartment of Microbiology and Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Sarah L BainesDepartment of Microbiology and Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Iain J AbbottDepartment of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Denis W SpelmanDepartment of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Xenia KostouliasInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Cara NethercottInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Benjamin P HowdenInfectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia.
Anton Y PelegInfection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia anton.peleg@monash.edu.
Monash University · AUAustralian Regenerative Medicine Institute · AUPeter Doherty Institute · AUThe Alfred Hospital · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coagulase-negative staphylococci (CoNS) represent one of the major causes of health care- and medical device-associated infections. Emerging antimicrobial resistance has complicated the treatment of systemic infections caused by CoNS. Here, we describe the prevalence of antimicrobial resistance in clinical CoNS strains from a tertiary care hospital over a 4-year period, and we observed a significant increase in resistance to daptomycin. Notably,

Indexed as

Amino Acid SubstitutionAnti-Bacterial AgentsBacterial ProteinsBiofilmsCross InfectionDaptomycinDrug Resistance, BacterialHistidine KinaseHumansMicrobial Sensitivity TestsPolymorphism, Single NucleotideStaphylococcal InfectionsStaphylococcus aureusStaphylococcus capitisStaphylococcus epidermidisTertiary Care CentersAnti-Bacterial AgentsBacterial ProteinsDaptomycinHistidine KinaseVancomycinYycF protein, Bacteriacoagulase-negative staphylococcidaptomycinwalKR

Identifiers

PMID30617095
PMCPMC6395924
OpenAlexW2909855698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.