ReviewCold Spring Harbor perspectives in medicine2020
Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms.
Review in Cold Spring Harbor perspectives in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04862572 (Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss), which is not on this map. Cited by 81 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Disinhibitory Brain Mechanism in Tinnitus and Hearing Loss: Is There a Maladaptive Signature of Auditory Cortex GABA Loss and Dysconnectivity?
Who cites it
81 citing papers in PubMed, 127 citations in OpenAlex.
- Early Detection of Blast-Induced Hidden Hearing Loss in Military Personnel Using an Extended Audiological Battery.Diagnostics (Basel, Switzerland) · 2026Article
- Aging Alters Hair Cell Physiological Properties in Mice With Late-Onset Age-Related Hearing Loss.Aging cell · 2026Article
- Hidden and Delayed-Onset Hearing Loss in Children: Limitations of Newborn Hearing Screening and Future Directions.Children (Basel, Switzerland) · 2026Review
- The Gut-Ear Axis: From Dysbiosis to Auditory and Vestibular Disorders.International journal of molecular sciences · 2026Review
- Longitudinal Evaluation of Otoacoustic Emissions as a Screening Tool for High-Frequency Hearing Loss in Adolescents.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Broadband Noise Acoustic Stapedial Reflex Thresholds as a Marker of Cochlear and Neural Integrity in Individuals with Normal Audiograms.Audiology research · 2026Article
- Temporal integration in the subcortical auditory system and behavioral evidence of its dysfunction after "temporary" noise-induced hearing loss.bioRxiv : the preprint server for biology · 2026Article
- Auditory-Motor Mechanisms of the Lombard Effect.Journal of speech, language, and hearing research : JSLHR · 2026Article
- Potential Risk for Hearing from Prolonged Exposure to Sound at Conversation Levels.Audiology research · 2026Article
- Cochlear synaptic vulnerability scales with pathological noise intensity in a noise-induced hearing loss model.Genes & genomics · 2026Article
- Brimonidine Therapy for Protection From Noise-Induced Hearing Loss.Aging cell · 2026Article
- Impacts of heminode disruption on auditory processing of noisy sound stimuli.bioRxiv : the preprint server for biology · 2026Article
- Persistent impairment of spatial hearing and neural binaural interaction after "temporary" noise-induced hearing loss.bioRxiv : the preprint server for biology · 2026Article
- Is allergic rhinitis associated with hidden hearing loss in pediatric/adolescent patients? A cross-sectional study.Frontiers in pediatrics · 2026Article
- From Clinic to Reality: Integrating Sound Field Testing and Hearing Quality Measures in Cochlear Implant Users.Journal of clinical medicine · 2025Article
- Slight and hidden hearing loss differentially affect short- and long-term memory in young rats.Behavioural pharmacology · 2025Article
- Sleep Disturbances Associated With Hidden Hearing Loss: Insights From Human Data and a Mouse Model of Sleep Fragmentation.Brain and behavior · 2025Observational
- A Single Dose of AC102 Reverts Tinnitus by Restoring Ribbon Synapses in Noise-Exposed Mongolian Gerbils.International journal of molecular sciences · 2025Article
- The Auditory Brainstem Response Diagnoses Alzheimer-Like Disease in the 5xFAD Mouse Model.eNeuro · 2025Article
- A Systematic Review: State of the Science on Diagnostics of Hidden Hearing Loss.Diagnostics (Basel, Switzerland) · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Hidden hearing loss (HHL), a recently described auditory disorder, has been proposed to affect auditory neural processing and hearing acuity in subjects with normal audiometric thresholds, particularly in noisy environments. In contrast to central auditory processing disorders, HHL is caused by defects in the cochlea, the peripheral auditory organ. Noise exposure, aging, ototoxic drugs, and peripheral neuropathies are some of the known risk factors for HHL. Our knowledge of the causes and mechanisms of HHL are based primarily on animal models. However, recent clinical studies have also shed light on the etiology and prevalence of this cochlear disorder and how it may affect auditory perception in humans. Here, we review the current knowledge regarding the causes and cellular mechanisms of HHL, summarize information on available noninvasive tests for differential diagnosis, and discuss potential therapeutic approaches for treatment of HHL.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.