ArticleThe Journal of allergy and clinical immunology2019
Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4
Article in The Journal of allergy and clinical immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
- Sensing of DNA double-strand breaks by the NHEJ system stabilizes RORγt transcriptional activity and shapes Th17 pathogenicity in autoimmunity.Cell research · 2026Article
- Unexpected genetically determined immune dysregulation with liver involvement: GIMAP5 therapeutic dilemmas between targeted therapy and HSCT.Frontiers in immunology · 2026Article
- Identification and validation of GIMAP family genes as immune-related prognostic biomarkers in lung adenocarcinoma.Heliyon · 2024Article
- When ceramides meet immune senescence, a GIMAP5 connection.Nature immunology · 2024Article
- Inferred Causal Mechanisms of Persistent FMDV Infection in Cattle from Differential Gene Expression in the Nasopharyngeal Mucosa.Pathogens (Basel, Switzerland) · 2022Article
- Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis.Oncology letters · 2022Article
- Deep Proteomic Analysis on Biobanked Paraffine-Archived Melanoma with Prognostic/Predictive Biomarker Read-Out.Cancers · 2021Article
- GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension.The Journal of experimental medicine · 2021Article
- Gimap5 Inhibits Lung Cancer Growth by Interacting With M6PR.Frontiers in oncology · 2021Article
- Article
- [Subcellular localization of GTPase of immunity-associated protein 2].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Stressed: The Unfolded Protein Response in T Cell Development, Activation, and Function.International journal of molecular sciences · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGTPase of immunity-associated protein 5 (GIMAP5) is essential for lymphocyte homeostasis and survival. Recently, human GIMAP5 single nucleotide polymorphisms have been linked to an increased risk for asthma, whereas loss of Gimap5 in mice has been associated with severe CD4
objectiveWe sought to identify the molecular and cellular mechanisms by which Gimap5 deficiency predisposes to allergic airway disease.
methodsCD4
resultsGIMAP5 LOF mutations in both mice and human subjects are associated with spontaneous polarization toward pathogenic T
conclusionActivation of Gimap5-deficient CD4
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.