ArticleJournal of translational medicine2019
Establishment of clinical diagnosis model of Graves' disease and Hashimoto's thyroiditis.
Article in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Ultrasound Radiomics for Hashimoto's Thyroiditis: State of the Art and Future Perspectives.Journal of clinical ultrasound : JCU · 2026Review
- Heterozygous pathogenic variants inOpen life sciences · 2026Article
- Exploring the Comprehensive Treatment of Hashimoto's Thyroiditis with Traditional Chinese Medicine from the Perspective of Modern Medicine.Therapeutics and clinical risk management · 2026Review
- Qualitative and quantitative CEUS assessment for differential diagnosis in thyrotoxicosis: destruction vs. hyperfunction.Endocrine · 2025Article
- Identification of BTK as an immune-related biomarker for Hashimoto's thyroiditis by integrated bioinformatic analysis.BMC immunology · 2025Article
- Differential diagnosis of Hashimoto's thyroiditis: The importance of pathological anatomy.Journal of biological methods · 2025Review
- Analysis of risk factors for autoimmune thyroid disease based on blood indicators and urinary iodine concentrations.Frontiers in endocrinology · 2024Article
- The C55A Single Nucleotide Polymorphism inDiagnostics (Basel, Switzerland) · 2023Article
- Mapping the path towards novel treatment strategies: a bibliometric analysis of Hashimoto's thyroiditis research from 1990 to 2023.Frontiers in endocrinology · 2023Article
- Graves' Disease in Children: An Update.Clinical medicine insights. Endocrinology and diabetes · 2023Review
- A Review of Testing for Distinguishing Hashimoto's Thyroiditis in the Hyperthyroid Stage and Grave's Disease.International journal of general medicine · 2023Review
- A case report of new onset graves' disease induced by SARS-CoV-2 infection or vaccine?Journal of clinical and translational endocrinology case reports · 2022Article
- Prediction models constructed for Hashimoto's thyroiditis risk based on clinical and laboratory factors.Frontiers in endocrinology · 2022Article
- Correlation between serum 25-(OH)DExperimental and therapeutic medicine · 2021Article
- 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as a Cause of Autoimmune Thyroid Diseases (AITD) During Pregnancy?The Yale journal of biology and medicine · 2020Review
- A novel prognostic model for adult patients with Hemophagocytic Lymphohistiocytosis.Orphanet journal of rare diseases · 2020Article
- The study of multiple diagnosis models of human prostate cancer based on Taylor database by artificial neural networks.Journal of the Chinese Medical Association : JCMA · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA clinical diagnosis model include thyroid functions, thyroid antibodies and radioactive iodine uptake (RAIU) of patients with hyperthyroidism were established and as new evaluation indicators for the differentiation of the Graves' disease (GD) and Hashimoto's thyroiditis (HT).
methodsClinical data of patients with newly diagnosed hyperthyroidism including gender, age, thyroid function, thyroid antibodies (FT3, FT4, TSH, TPOAb, TGAb, TRAb), RAIU (2 h, 6 h, 24 h) were collected. A stepwise regression analysis was performed to establish a model based on these variables.
resultsModel 1 was subjected to stepwise regression analysis. After screening, the variables that entered the model included FT3, TGAb, TPOAb, TRAb, 2-h RAIU, 24-h RAIU and gender, in which the variables FT3, TGAb, TRAb, 2-h RAIU, 24-h RAIU, and gender were significantly different. Model 2 without RAIU was also subjected to stepwise regression analysis. After screening, the variables that entered the model included FT4, TGAb, TPOAb, TRAb and gender were statistical significant. The larger value of each variable in the two models indicated the higher probability to diagnose GD. The area under the receiver operating characteristic (ROC) curve of model 1 was 0.843 (95% CI 0.779-0.894), and the area under the ROC curve of model 2 was 0.806 (95% CI 0.685-0.824), which showed good differential diagnostic value.
conclusionsGD and HT diagnosis model was established according to the variables including gender, FT3, TGAb, TRAb, the 2-h RAIU, the 24-h RAIU in the model 1, and the variables FT4, TGAb, TPOAb, TRAb and gender in the model 2 that did not include RAIU. These models had high value to differentiate GD and HT for patients with early hyperthyroidism.
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