ArticleBMC complementary and alternative medicine2019
Antioxidants and α-glucosidase inhibitors from Neptunia oleracea fractions using
Article in BMC complementary and alternative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Phytochemical and antidiabetic evaluation of Bauhinia tomentosa L. aerial parts.BMC complementary medicine and therapies · 2026Article
- Effects of Exogenous Tannase and Papain on the Flavor Quality of Black Tea During Fermentation.Foods (Basel, Switzerland) · 2026Article
- The most commonly used spices in Thai traditional medicine:Research in pharmaceutical sciences · 2024Article
- Metabolomics based biomarker identification of anti-diabetes and anti-obesity properties of Malaysian herbs.Metabolomics : Official journal of the Metabolomic Society · 2022Review
- Biological Activities of Selected Plants and Detection of Bioactive Compounds fromMolecules (Basel, Switzerland) · 2020Article
- Psychopharmacological effects of riparin III from Aniba riparia (Nees) Mez. (Lauraceae) supported by metabolic approach and multivariate data analysis.BMC complementary medicine and therapies · 2020Article
- Analysis of Primary Metabolites in Cabbage (Molecules (Basel, Switzerland) · 2019Article
- Recent metabolomics and gene editing approaches for synthesis of microbial secondary metabolites for drug discovery and development.World journal of microbiology & biotechnology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeptunia oleracea is a plant cultivated as vegetable in Southeast Asia. Previous works have revealed the potential of this plant as a source of natural antioxidants and α-glucosidase inhibitors. Continuing our interest on this plant, the present work is focused in identification of the bioactive compounds from different polarity fractions of N. oleracea, namely hexane (HF), chloroform (CF), ethyl acetate (EF) and methanol (MF).
methodsThe N. oleracea fractions were obtained using solid phase extraction (SPE). A metabolomics approach that coupled the use of proton nuclear magnetic resonance (
resultsThe principal component analysis (PCA) discriminated EF and MF from the other fractions with the higher distributions of phenolics. Partial least squares (PLS) analysis revealed a strong correlation between the phenolics and the studied bioactivities in the EF and the MF. The UHPLC-MS/MS profiling of EF and MF had tentatively identified the phenolics present. Together with some non-phenolic metabolites, a total of 37 metabolites were tentatively assigned.
conclusionsThe findings of this work supported that N. oleracea is a rich source of phenolics that can be potential antioxidants and α-glucosidase inhibitors for the management of diabetes. To our knowledge, this study is the first report on the metabolite-bioactivity correlation and UHPLC-MS/MS analysis of N. oleracea fractions.
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