ArticleBMC plant biology2019
Phytohormone treatment induces generation of cryptic peptides with antimicrobial activity in the Moss Physcomitrella patens.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 36 citations in OpenAlex.
- Natural variation in antimicrobial activity and composition of the secreted metabolomes of the model moss Ceratodon purpureus.Scientific reports · 2026Article
- The 'non-conventional' peptidome: A new layer in plant regulatory mechanisms.Plant communications · 2025Review
- Proteostasis and protein quality control in chloroplasts: mechanisms and novel insights related to protein mislocalization.Journal of experimental botany · 2025Review
- Exploring the Antimicrobial and Antiviral Properties of Cryptic Peptides from Human Fibrinogen.International journal of molecular sciences · 2025Article
- The Proteomic and Peptidomic Response of Wheat (Plants (Basel, Switzerland) · 2025Article
- Antimicrobial Peptides: Mechanisms, Applications, and Therapeutic Potential.Infection and drug resistance · 2025Review
- Transcriptional and functional characterization in the terpenoid precursor pathway of the early land plant Physcomitrium patens.Plant biology (Stuttgart, Germany) · 2025Article
- Applications of tandem mass spectrometry (MS/MS) in antimicrobial peptides field: Current state and new applications.Heliyon · 2024Review
- Diversity and Mechanisms of Action of Plant, Animal, and Human Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2024Review
- Emerging therapeutic options in the management of diabetes: recent trends, challenges and future directions.International journal of obesity (2005) · 2023Review
- Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning.Cell host & microbe · 2023Article
- Article
- Antimicrobial Activities of Secondary Metabolites from Model Mosses.Antibiotics (Basel, Switzerland) · 2022Article
- Effect of FKBP12-Derived Intracellular Peptides on Rapamycin-Induced FKBP-FRB Interaction and Autophagy.Cells · 2022Article
- Peptidome: Chaos or Inevitability.International journal of molecular sciences · 2021Review
- Phytohormone biosynthesis and signaling pathways of mosses.Plant molecular biology · 2021Review
- A vast pool of lineage-specific microproteins encoded by long non-coding RNAs in plants.Nucleic acids research · 2021Article
- Possible role of small secreted peptides (SSPs) in immune signaling in bryophytes.Plant molecular biology · 2021Article
- Bioactive role of plant stress hormone methyl jasmonate against lipopolysaccharide induced arthritis.Heliyon · 2020Article
- The Role of Peptide Signals Hidden in the Structure of Functional Proteins in Plant Immune Responses.International journal of molecular sciences · 2019Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCryptic peptides (cryptides) are small bioactive molecules generated via degradation of functionally active proteins. Only a few examples of plant cryptides playing an important role in plant defense have been reported to date, hence our knowledge about cryptic signals hidden in protein structure remains very limited. Moreover, little is known about how stress conditions influence the size of endogenous peptide pools, and which of these peptides themselves have biological functions is currently unclear.
resultsHere, we used mass spectrometry to comprehensively analyze the endogenous peptide pools generated from functionally active proteins inside the cell and in the secretome from the model plant Physcomitrella patens. Overall, we identified approximately 4,000 intracellular and approximately 500 secreted peptides. We found that the secretome and cellular peptidomes did not show significant overlap and that respective protein precursors have very different protein degradation patterns. We showed that treatment with the plant stress hormone methyl jasmonate induced specific proteolysis of new functional proteins and the release of bioactive peptides having an antimicrobial activity and capable to elicit the expression of plant defense genes. Finally, we showed that the inhibition of protease activity during methyl jasmonate treatment decreased the secretome antimicrobial potential, suggesting an important role of peptides released from proteins in immune response.
conclusionsUsing mass-spectrometry, in vitro experiments and bioinformatics analysis, we found that methyl jasmonate acid induces significant changes in the peptide pools and that some of the resulting peptides possess antimicrobial and regulatory activities. Moreover, our study provides a list of peptides for further study of potential plant cryptides.
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