Observational studyJournal of psychopharmacology (Oxford, England)2019
Risk of readmission in patients with schizophrenia and schizoaffective disorder newly prescribed clozapine.
Observational study in Journal of psychopharmacology (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Ethnic disparities in clozapine prescription for service-users with schizophrenia-spectrum disorders: a systematic review.Psychological medicine · 2022Pooled it
- Clozapine levels in inpatients with schizophrenia are not a predictor of rehospitalization: a naturalistic retrospective study.Pharmacological reports : PR · 2026Article
- Clozapine, relapse, and adverse events: a 10-year electronic cohort study in Canada.The British journal of psychiatry : the journal of mental science · 2024Article
- Article
- Examining racial disparity in psychotic disorders related ambulatory care visits: an observational study using national ambulatory medical care survey 2010-2015.BMC psychiatry · 2023Observational
- Ethnic inequalities in clozapine use among people with treatment-resistant schizophrenia: a retrospective cohort study using data from electronic clinical records.Social psychiatry and psychiatric epidemiology · 2022Article
- Efficacy of clozapine for long-stay patients with treatment-resistant schizophrenia: 4-year observational study.Neuropsychopharmacology reports · 2022Observational
- Using a statistical learning approach to identify sociodemographic and clinical predictors of response to clozapine.Journal of psychopharmacology (Oxford, England) · 2022Article
- COVID-related hospitalization, intensive care treatment, and all-cause mortality in patients with psychosis and treated with clozapine.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2022Article
- Clozapine treatment and risk of COVID-19 infection: retrospective cohort study.The British journal of psychiatry : the journal of mental science · 2021Article
- Article
- Impact of the COVID-19 pandemic on remote mental healthcare and prescribing in psychiatry: an electronic health record study.BMJ open · 2021Article
- Clozapine prescribing: comparison of clozapine dosage and plasma levels between White British and Bangladeshi patients.BJPsych bulletin · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInsight into the effect of clozapine is limited by a lack of controlling for confounding variables in current research. Our objective was to investigate the association between clozapine prescribed at discharge, following an inpatient episode, and risk of readmission into secondary mental health services in patients with schizophrenia and schizoaffective disorder, controlling extensively for confounding variables.
methodsClinical records from 3651 patients were analysed in a retrospective observational cohort study. Cox proportional-hazards regression models were used to assess the risk of hospital readmission. A series of sensitivity analyses were also conducted. Propensity score methods were used to address confounding-by-indication.
resultsPatients on clozapine ( n=202) had a reduced risk of readmission compared with patients on other antipsychotics (adjusted hazard ratio=0.79; 95% confidence interval: 0.64-0.99; p=0.043). Clozapine also had a protective effect on risk of readmission when compared with olanzapine (adjusted hazard ratio 0.76; 95% confidence interval: 0.60-0.96; p=0.021). The effect size remained consistent after adjusting for an array of possible confounders, as well as using propensity scores to address confounding-by-indication. A statistically significant result was also noted in all but two sensitivity analyses.
conclusionOur findings suggest that clozapine is associated with a reduced risk of readmission into secondary mental health services.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.