ArticleJournal of the American Heart Association2019
Associations of Accelerometer-Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study.
Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Lifestyle-Induced Visceral Fat Loss as a Key Target for Durable Cardiometabolic Health: MRI-Assessed 5- and 10-Year Follow-Up After 2 Clinical Trials.Circulation · 2026Trial
- Joint association of depression and physical activity with incident cardiometabolic multimorbidity (CMM) among middle-aged and older adults in China.Scientific reports · 2026Article
- The association between perceived 15-minute fitness circle accessibility and physical activity in China: the mediating role of informal social support.International journal for equity in health · 2025Article
- Data Analytics in Physical Activity Studies With Accelerometers: Scoping Review.Journal of medical Internet research · 2024Article
- Reallocating just 10 min to moderate-to-vigorous physical activity from other components of 24-hour movement behaviors improves cardiovascular health in adults.BMC public health · 2024Article
- Prospective association of daily ambulatory activity with metabolic syndrome in middle-aged and older Japanese adults: the Toon Health Study.International journal of obesity (2005) · 2024Article
- Non-alcoholic fatty liver modifies associations of body mass index and waist circumference with cardiometabolic risk: The CARDIA study.Obesity science & practice · 2024Article
- Exercise Is a Vital Sign.HCA healthcare journal of medicine · 2024Review
- Replacing device-measured sedentary time with physical activity is associated with lower risk of coronary heart disease regardless of genetic risk.Journal of internal medicine · 2024Article
- Associations of Physical Activity and Lactation Duration With Cardiometabolic Risk Factors: The CARDIA Study.JACC. Advances · 2023Article
- Substituting device-measured sedentary time with alternative 24-hour movement behaviours: compositional associations with adiposity and cardiometabolic risk in the ORISCAV-LUX 2 study.Diabetology & metabolic syndrome · 2023Article
- A Cross-Sectional Investigation of Preadolescent Cardiometabolic Health: Associations with Fitness, Physical Activity, Sedentary Behavior, Nutrition, and Sleep.Children (Basel, Switzerland) · 2023Article
- Compositional analysis of movement behaviors' association on high-sensitivity c-reactive protein: the Jackson heart study.Annals of epidemiology · 2022Article
- Social epidemiology of early adolescent problematic screen use in the United States.Pediatric research · 2022Article
- Cardiometabolic factors explaining the association between physical activity and quality of life: U.S. National Health and Nutrition Examination Survey.Journal of exercise science and fitness · 2022Article
- Sedentary Behaviors and Health Outcomes among Young Adults: A Systematic Review of Longitudinal Studies.Healthcare (Basel, Switzerland) · 2022Review
- Moderate-to-vigorous intensity physical activity from young adulthood to middle age and metabolic disease: a 30-year population-based cohort study.British journal of sports medicine · 2022Article
- Is Sedentary Behavior a Novel Risk Factor for Cardiovascular Disease?Current cardiology reports · 2022Review
- Physical activity intensity profiles associated with cardiometabolic risk in middle-aged to older men and women.Preventive medicine · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005-2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015-2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score (-0.01 SD [95% CI, -0.02, -0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, -0.27, 0.02]), insulin (0.20 μU/mL [95% CI, -0.35, -0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (-0.08 [95% CI, -0.13, -0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, -2.21, -0.84]), insulin (-1.13 μU/mL [95% CI, -1.95, -0.31]), triglycerides (-6.92 mg/dL [95% CI, -11.69, -2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.
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