Evidence map›Paper›PMID 30615986›Full record

ReviewBrain and language2019

Knowledge of language function and underlying neural networks gained from focal seizures and epilepsy surgery.

Daniel L Drane, Nigel P Pedersen

Open access · greenAbstract readReview
In one paragraph

Review in Brain and language, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Beyond Broca and Wernicke: Epilepsy surgery in the language areas.Epileptic disorders : international epilepsy journal with videotape · 2026
    Review
  4. Article
  5. Article
  6. Hyperphosphorylated Tau and Cognition in Epilepsy.Journal of clinical medicine · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Rationale and Design of the National Neuropsychology Network.Journal of the International Neuropsychological Society : JINS · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Cognitive and Emotional Mapping With SEEG.Frontiers in neurology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Daniel L DraneDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA; Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: ddrane@emory.edu.
Nigel P PedersenDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Emory University · USUniversity of Washington · US

Funding

Dissecting the Cognitive Roles of Hippocampus, Other Temporal Lobe StructuresR01NS088748 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2014 to 2024
$6.4M
Semantic Deficits in Temporal Lobe Epilepsy Surgical Patients May Represent A StrK02NS070960 · NINDS · EMORY UNIVERSITY · PI DRANE, DANIEL L · 2011 to 2015
$827k
NINDS NIH HHS K02 NS070960NINDS NIH HHS L30 NS080215NINDS NIH HHS R01 NS088748
6 · The paper itself

Abstract

The effects of epilepsy and its treatments have contributed significantly to language models. The setting of epilepsy surgery, which allows for careful pre- and postsurgical evaluation of patients with cognitive testing and neuroimaging, has produced a wealth of language findings. Moreover, a new wave of surgical interventions, including stereotactic laser ablation and radio frequency ablation, have contributed new insights and corrections to language models as they can make extremely precise, focal lesions. This review covers the common language deficits observed in focal dyscognitive seizure syndromes. It also addresses the effects of surgical interventions on language, and highlights insights gained from unique epilepsy assessment methods (e.g., cortical stimulation mapping, Wada evaluation). Emergent findings are covered including a lack of involvement of the hippocampus in confrontation word retrieval, possible roles for key white matter tracts in language, and the often-overlooked basal temporal language area. The relationship between language and semantic memory networks is also explored, with brief consideration given to the prevailing models of semantic processing, including the amodal Hub and distributed, multi-modal processing models.

Indexed as

Nerve NetSemanticsSpeech PerceptionAdolescentBrainBrain MappingEpilepsyFemaleHumansLanguage DisordersMaleMemoryDevelopmentEpilepsyLanguage functionsNeural substratesSurgical effects

Identifiers

PMID30615986
PMCPMC7183240
OpenAlexW2907623380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.