Evidence map›Paper›PMID 30615938›Full record

ArticleJournal of biomedical informatics2019

Rapamycin - mTOR + BRAF = ? Using relational similarity to find therapeutically relevant drug-gene relationships in unstructured text.

Safa Fathiamini, Amber M Johnson, Jia Zeng, Vijaykumar Holla, Nora S Sanchez, Funda Meric-Bernstam, Elmer V Bernstam, Trevor Cohen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical informatics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Safa FathiaminiSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, TX, United States. Electronic address: Safa.Fathiamini@uth.tmc.edu.
Amber M JohnsonSheikh Khalifa Al Nahyan Ben Zayed Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Jia ZengSheikh Khalifa Al Nahyan Ben Zayed Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Vijaykumar HollaSheikh Khalifa Al Nahyan Ben Zayed Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Nora S SanchezSheikh Khalifa Al Nahyan Ben Zayed Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Funda Meric-BernstamSheikh Khalifa Al Nahyan Ben Zayed Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Elmer V BernstamSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, TX, United States; Division of General Internal Medicine, Department of Internal Medicine, The University of Texas Health Science Center at Houston, TX, United States. Electronic address: Elmer.V.Bernstam@uth.tmc.edu.
Trevor CohenDepartment of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, United States. Electronic address: cohenta@uw.edu.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
UT Southwestern Center for Translational Medicine (UL1/KL2/TL1)UL1TR001105 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$24.5M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
Using Biomedical Knowledge to Identify Plausible Signals for PharmacovigilanceR01LM011563 · NLM · UNIVERSITY OF WASHINGTON · PI COHEN, TREVOR · 2013 to 2020
$3.0M
Informatics Tools for Pharmacogenomic Discovery using Practice-based DataR01GM103859 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C., PATHAK, JYOTISHMAN · 2014 to 2017
$2.4M
Informatics to enable routine personalized cancer therapyU01CA180964 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERNSTAM, ELMER V., MERIC-BERNSTAM, FUNDA · 2013 to 2015
$964k
UT Southwestern Center for Translational Medicine (UL18Kl2/TL1)TL1TR001104 · NCATS · UT SOUTHWESTERN MEDICAL CENTER · PI TOTO, ROBERT DANIEL · 2013 to 2017
$418k
NCATS NIH HHS TL1 TR001104NCATS NIH HHS UL1 TR000371NCATS NIH HHS UL1 TR001105NCI NIH HHS P30 CA016672NCI NIH HHS U01 CA180964NIGMS NIH HHS R01 GM103859NLM NIH HHS R01 LM011563
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Data MiningHumansProto-Oncogene Proteins B-rafSirolimusTOR Serine-Threonine KinasesBRAF protein, humanMTOR protein, humanProto-Oncogene Proteins B-rafSirolimusTOR Serine-Threonine KinasesAttributional similarityNeural word embeddingsPharmacogenomicsPrecision oncologyRandom IndexingRelational similarity

Identifiers

PMID30615938
PMCPMC6386529

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.