SynthesisNeuroscience and biobehavioral reviews2019
The structural connectome in traumatic brain injury: A meta-analysis of graph metrics.
Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Brain network properties in chronic pain-a systematic review and meta-analysis of graph-based connectivity metrics.Frontiers in neuroscience · 2025Pooled it
- Global Alterations of Whole Brain Structural Connectome in Parkinson's Disease: A Meta-analysis.Neuropsychology review · 2023Pooled it
- Graph Theoretical Analysis of Brain Network Characteristics in Brain Tumor Patients: A Systematic Review.Neuropsychology review · 2022Pooled it
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks.JAMA psychiatry · 2026Article
- Longitudinal Multimodal Neuroimaging After Traumatic Brain Injury.Human brain mapping · 2026Article
- Multiscale network perspectives on glioma: from tumour biology to symptoms, survival and treatment.Nature reviews. Neurology · 2026Review
- Connectome disruptions after hypoxic-ischaemic injury associate with consciousness disorder severity.Brain communications · 2026Article
- Harmonized connectome resampling for variance in voxel sizes.Magnetic resonance imaging · 2025Article
- Apathy, gait slowness, and executive dysfunction (AGED) triad: opportunities to predict and delay dementia onset.GeroScience · 2025Article
- Mapping ADHD Heterogeneity and Biotypes through Topological Deviations in Morphometric Similarity Networks.medRxiv : the preprint server for health sciences · 2025Article
- Brain activity dynamics after traumatic brain injury indicate increased state transition energy and preference of lower order states.NeuroImage. Clinical · 2025Article
- Impact of moderate aerobic exercise on small-world topology and characteristics of brain networks after sport-related concussion: an exploratory study.Scientific reports · 2024Article
- Characteristics of the Structural Connectivity in Patients with Brain Injury and Chronic Health Symptoms: A Pilot Study.Neuroinformatics · 2024Article
- Identification and Connectomic Profiling of Concussion Using Bayesian Machine Learning.Journal of neurotrauma · 2024Article
- Graph Analysis of the Visual Cortical Network during Naturalistic Movie Viewing Reveals Increased Integration and Decreased Segregation Following Mild TBI.Vision (Basel, Switzerland) · 2024Article
- Learning site-invariant features of connectomes to harmonize complex network measures.Proceedings of SPIE--the International Society for Optical Engineering · 2024Article
- Prediction of cognitive outcome after mild traumatic brain injury from acute measures of communication within brain networks.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Altered grey matter structural covariance in chronic moderate-severe traumatic brain injury.Scientific reports · 2024Article
- Neuroimaging Correlates of Functional Outcome Following Pediatric TBI.Advances in neurobiology · 2024Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Although recent structural connectivity studies of traumatic brain injury (TBI) have used graph theory to evaluate alterations in global integration and functional segregation, pooled analysis is needed to examine the robust patterns of change in graph metrics across studies. Following a systematic search, 15 studies met the inclusion criteria for review. Of these, ten studies were included in a random-effects meta-analysis of global graph metrics, and subgroup analyses examined the confounding effects of severity and time since injury. The meta-analysis revealed significantly higher values of normalised clustering coefficient (gö=ö1.445, CI=[0.512, 2.378], pö=ö0.002) and longer characteristic path length (gö=ö0.514, CI=[0.190, 0.838], pö=ö0.002) in TBI patients compared with healthy controls. Our findings suggest that the TBI structural network has shifted away from the balanced small-world network towards a regular lattice. Therefore, these graph metrics may be useful markers of neurocognitive dysfunction in TBI. We conclude that the pattern of change revealed by our analysis should be used to guide hypothesis-driven research into the role of graph metrics as diagnostic and prognostic biomarkers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.