SynthesisNeuroscience and biobehavioral reviews2019
Variation in fourteen brain structure volumes in schizophrenia: A comprehensive meta-analysis of 246 studies.
Synthesis in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 152 citations in OpenAlex.
- Emotion Processing in Schizophrenia: Insights From a Brain Imaging Study Comparing Patients, Siblings, and Healthy Controls.Human brain mapping · 2026Trial
- Effects of Exercise on Structural and Functional Brain Patterns in Schizophrenia-Data From a Multicenter Randomized-Controlled Study.Schizophrenia bulletin · 2024Trial
- Schizophrenia, variability, and the Anna Karenina principle.Psychiatry research. Neuroimaging · 2026Article
- The Molecular Machinery of Synaptic Plasticity and Its Potential Role in the Aetiology of Schizophrenia.Molecular neurobiology · 2026Review
- Use of Z-Scores and Percentages to Assess Structural Brain MRI Findings in Patients With Schizophrenia.International journal of methods in psychiatric research · 2026Article
- Associations of inflammatory biomarkers with brain atrophy and clinical scores in schizophrenia patients with autistic features.BMC research notes · 2026Article
- Normative age-related structural brain deviations underlying psychopathology, cognitive impairment and neurological soft signs in schizophrenia spectrum disorders.Translational psychiatry · 2026Article
- Altered neural processing in middle frontal gyrus and cerebellum during temporal recalibration of action-outcome predictions in schizophrenia spectrum disorders.Schizophrenia (Heidelberg, Germany) · 2026Article
- Shared genetic effects among schizophrenia, substance use disorder, and hippocampal volume in a multiplex extended pedigree sample.Schizophrenia research · 2026Article
- Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease.Cells · 2025Review
- Neural and somatic mechanisms driving clinical improvements in post-acute schizophrenia spectrum disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- MesoSCOUT: A novel tool for revealing mesoscale organization in the white-matter connectome.bioRxiv : the preprint server for biology · 2025Article
- Tobacco Smoking and Gray Matter Volume in Individuals at Clinical High Risk for Psychosis: A Longitudinal Magnetic Resonance Imaging Study.Biological psychiatry global open science · 2025Article
- Analysis of Factors Affecting Quality in Structural Magnetic Resonance Images.Human brain mapping · 2025Article
- Estrogen and psychosis - a review and future directions.Archives of women's mental health · 2024Review
- Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic.Physiological research · 2024Review
- Dysregulation of myelination-related genes in schizophrenia.Journal of neurochemistry · 2024Review
- Schizophrenia: from neurochemistry to circuits, symptoms and treatments.Nature reviews. Neurology · 2024Review
- Understanding copy number variations through their genes: a molecular view on 16p11.2 deletion and duplication syndromes.Frontiers in pharmacology · 2024Review
- Investigating amplitude of low-frequency fluctuation and possible links with cognitive impairment in childhood and adolescence onset schizophrenia: a correlation study.Frontiers in psychiatry · 2024Article
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Abstract
Despite hundreds of structural MRI studies documenting smaller brain volumes on average in schizophrenia compared to controls, little attention has been paid to group differences in the variability of brain volumes. Examination of variability may help interpret mean group differences in brain volumes and aid in better understanding the heterogeneity of schizophrenia. Variability in 246 MRI studies was meta-analyzed for 13 structures that have shown medium to large mean effect sizes (Cohen's d≥0.4): intracranial volume, total brain volume, lateral ventricles, third ventricle, total gray matter, frontal gray matter, prefrontal gray matter, temporal gray matter, superior temporal gyrus gray matter, planum temporale, hippocampus, fusiform gyrus, insula; and a control structure, caudate nucleus. No significant differences in variability in cortical/subcortical volumes were detected in schizophrenia relative to controls. In contrast, increased variability was found in schizophrenia compared to controls for intracranial and especially lateral and third ventricle volumes. These findings highlight the need for more attention to ventricles and detailed analyses of brain volume distributions to better elucidate the pathophysiology of schizophrenia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.