Evidence map›Paper›PMID 30615907›Full record

ArticleMolecular and cellular endocrinology2019

Bisphenol A induces human uterine leiomyoma cell proliferation through membrane-associated ERα36 via nongenomic signaling pathways.

Linda Yu, Parikshit Das, Alejandra J Vall, Yitang Yan, Xioahua Gao, Maria I Sifre, Carl D Bortner, Lysandra Castro, Grace E Kissling, Alicia B Moore and 1 more

Abstract read
In one paragraph

Article in Molecular and cellular endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  8. Review
  9. Review
  10. Impact of bisphenol A on cell viability and inflammatory cytokine production in human cervical epithelial cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023
    Article
  11. Review
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  19. The role of endocrine-disrupting chemicals in uterine fibroid pathogenesis.Current opinion in endocrinology, diabetes, and obesity · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Linda YuMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA.
Parikshit DasMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA.
Alejandra J VallMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA.
Yitang YanMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA.
Xioahua GaoMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA.
Maria I SifreFlow Cytometry Center, Signal Transduction Laboratory, Research Triangle Park, NC, 27709, USA.
Carl D BortnerFlow Cytometry Center, Signal Transduction Laboratory, Research Triangle Park, NC, 27709, USA.
Lysandra CastroMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA.
Grace E KisslingBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (HHS), Research Triangle Park, NC, 27709, USA.
Alicia B MooreMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA.
Darlene DixonMolecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP (DNTP), Research Triangle Park, NC, 27709, USA. Electronic address: dixon@niehs.nih.gov.
Research Triangle Park Foundation · USNational Institutes of Health · US

Funding

Pathobiology Of Uterine Leiomyomas (fibroids)ZIAES021196 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DIXON, DARLENE · 2009 to 2025
$31.7M
Intramural NIH HHS ZIA ES021196
6 · The paper itself

Abstract

The role of ERα36 in regulating BPA's effects and its potential as a risk factor for human uterine fibroids were evaluated. BPA at low concentrations (10

Indexed as

Benzhydryl CompoundsBisphenol A CompoundsCell CycleCell Line, TumorCell ProliferationDose-Response Relationship, DrugEstrogen Receptor alphaFemaleGene Expression RegulationGRB2 Adaptor ProteinHumansLeiomyomaPhenolsPhosphorylationSignal TransductionSOS1 ProteinBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEstrogen Receptor alphaestrogen receptor alpha 36, humanGRB2 Adaptor ProteinGRB2 protein, humanPhenolsSOS1 ProteinSOS1 protein, humanBisphenol AEstrogen receptor alpha36 (ERα36)Leiomyoma cellsNongenomic signaling

Identifiers

PMID30615907
PMCPMC6450385
OpenAlexW2907788483

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.