Evidence map›Paper›PMID 30615803›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2019

Effects of High-Fat Diet and Body Mass on Bone Morphology and Mechanical Properties in 1100 Advanced Intercross Mice.

Matthew J Silva, Jeremy D Eekhoff, Tarpit Patel, Jane P Kenney-Hunt, Michael D Brodt, Karen Steger-May, Erica L Scheller, James M Cheverud

Open access · bronzeAbstract read
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 49 citations in OpenAlex.

  1. Review
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  8. Maternal high-fat high-sugar diet impairs bone quality and strength but not cartilage in aging mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Bone metabolism - an underappreciated player.npj metabolic health and disease · 2024
    Review
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Matthew J SilvaDepartment of Orthopaedic Surgery, Washington University in Saint Louis, St. Louis, MO, USA.
Jeremy D EekhoffDepartment of Biomedical Engineering, Washington University in Saint Louis, St. Louis, MO, USA.
Tarpit PatelDepartment of Orthopaedic Surgery, Washington University in Saint Louis, St. Louis, MO, USA.
Jane P Kenney-HuntDepartment of Anatomy and Neurobiology, Washington University in Saint Louis, St. Louis, MO, USA.
Michael D BrodtDepartment of Orthopaedic Surgery, Washington University in Saint Louis, St. Louis, MO, USA.
Karen Steger-MayDivision of Biostatistics, Washington University in Saint Louis, St. Louis, MO, USA.
Erica L SchellerDivision of Bone and Mineral Diseases, Department of Medicine, Washington University in Saint Louis, St. Louis, MO, USA.
James M CheverudDepartment of Anatomy and Neurobiology, Washington University in Saint Louis, St. Louis, MO, USA.
Washington University in St. Louis · USSaint Louis University · ES

Funding

Response of the Osteoporotic Skeleton to Mechanical LoadingR01AR047867 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2001 to 2026
$8.4M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
The Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2009 to 2018
$5.7M
Genetic Environmental Relationship Between Bone, Obesity and Leptin in MiceR01DK075112 · NIDDK · WASHINGTON UNIVERSITY · PI CHEVERUD, JAMES M · 2006 to 2010
$1.5M
Neural regulation of skeletal biology and periodontal disease progression in typeR00DE024178 · NIDCR · WASHINGTON UNIVERSITY · PI SCHELLER, ERICA LYNN · 2016 to 2018
$735k
NIAMS NIH HHS P30 AR057235NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR047867NIDCR NIH HHS R00 DE024178NIDDK NIH HHS R01 DK075112
6 · The paper itself

Abstract

Obesity is generally protective against osteoporosis and bone fracture. However, recent studies indicate that the influence of obesity on the skeleton is complex and can be detrimental. We evaluated the effects of a high-fat, obesogenic diet on the femur and radius of 1100 mice (males and females) from the Large-by-Small advanced intercross line (F

Indexed as

AnimalsBody WeightDietary FatsFemaleFemurMaleMiceObesityRadiusDietary FatsBIOMECHANICSBONEBONE MORPHOLOGYHIGH-FAT DIETOBESITYOSTEOPOROSIS

Identifiers

PMID30615803
PMCPMC6879418
OpenAlexW2909867458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.