ArticleBiomedical optics express2018
Quantified elasticity mapping of retinal layers using synchronized acoustic radiation force optical coherence elastography.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Phantoms for use in optical coherence elastography.Journal of biomedical optics · 2026Review
- Soft matrix promotes ciliogenesis in human retinal pigment epithelial cells.Scientific reports · 2026Article
- In vivo elastography of the human retina using light-evoked intrinsic actuation.bioRxiv : the preprint server for biology · 2026Article
- Substrate stiffness and pressure alter retinal Müller glia response and extracellular matrix production.Biomaterials and biosystems · 2025Article
- Retinal thermal deformations measured with phase-sensitive optical coherence tomography in vivo.Light, science & applications · 2025Article
- Structural effects of intraretinal cysts on outer retinal layers in eyes with diabetic macular edema.International journal of retina and vitreous · 2024Article
- Assessment of OCT-Based Macular Curvature and Its Relationship with Macular Microvasculature in Children with Anisomyopia.Ophthalmology and therapy · 2024Article
- The mechanics of the retina: Müller glia role on retinal extracellular matrix and modelling.Frontiers in medicine · 2024Review
- Biomarkers of Vitreous Cortex Remnants in Eyes With Primary Rhegmatogenous Retinal Detachment.Translational vision science & technology · 2023Article
- Pathophysiology of outer retinal corrugations: Imaging dataset and mechanical models.Data in brief · 2023Article
- Co-axial acoustic-based optical coherence vibrometry probe for the quantification of resonance frequency modes in ocular tissue.Scientific reports · 2022Article
- Article
- Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Interferometric imaging of thermal expansion for temperature control in retinal laser therapy.Biomedical optics express · 2022Article
- Pulsatile tissue deformation dynamics of the murine retina and choroid mapped by 4D optical coherence tomography.Biomedical optics express · 2022Article
- Temporal phase evolution OCT for measurement of tissue deformation in the human retinaBiomedical optics express · 2021Article
- Biomechanical properties of retina and choroid: a comprehensive review of techniques and translational relevance.Eye (London, England) · 2021Review
- 2-D Ultrasonic Array-Based Optical Coherence Elastography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Can the Macula be Attached if View Is Obscured by a Bullous Retinal Detachment? A Mathematical Consideration.Translational vision science & technology · 2021Article
- Layer-specific ultrasound elastography using a multi-layered shear wave dispersion model for assessing the viscoelastic properties.Physics in medicine and biology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly (over the age of 60 years) in western countries. In the early stages of the disease, structural changes may be subtle and cannot be detected. Recently it has been postulated that the mechanical properties of the retina may change with the onset of AMD. In this manuscript, we present a novel, non-invasive means that utilizes synchronized acoustic radiation force optical coherence elastography (ARF-OCE) to measure and estimate the elasticity of cadaver porcine retina. Both regions near the optic nerve and in the peripheral retina were studied. An acoustic force is exerted on the tissue for excitation and the resulting tissue vibrations, often in the nanometer scale, are detected with high-resolution optical methods. Segmentation has been performed to isolate individual layers and the Young's modulus has been estimated for each. The results have been successfully compared and mapped to corresponding histological results using H&E staining. Finally, 64 elastograms of the retina were analyzed, as well as the elastic properties, with stiffness ranging from 1.3 to 25.9 kPa in the ganglion to the photoreceptor sides respectively. ARF-OCE allows for the elasticity mapping of anatomical retinal layers. This imaging approach needs further evaluation but has the potential to allow physicians to gain a better understanding of the elasticity of retinal layers in retinal diseases such as AMD.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.