ArticleBiomedical optics express2018
Laser-activated perfluorocarbon nanodroplets: a new tool for blood brain barrier opening.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Intrathecal Delivery of Macromolecules to the Spinal Cord Enabled by Laser-Activated Perfluorocarbon Nanodroplets.ACS nano medicine · 2026Article
- Laser-activated perfluorocarbon nanodroplets for intracerebral delivery and imaging via blood-brain barrier opening and contrast-enhanced imaging.Journal of nanobiotechnology · 2024Article
- Factors Influencing the Repeated Transient Optical Droplet Vaporization Threshold and Lifetimes of Phase Change, Perfluorocarbon Nanodroplets.Nanomaterials (Basel, Switzerland) · 2023Article
- EGFR-Targeted Perfluorohexane Nanodroplets for Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2022Article
- Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents.Medical physics · 2022Article
- Repeated Acoustic Vaporization of Perfluorohexane Nanodroplets for Contrast-Enhanced Ultrasound Imaging.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Ultrasonic technologies in imaging and drug delivery.Cellular and molecular life sciences : CMLS · 2021Review
- Repetitive optical coherence elastography measurements with blinking nanobombs.Biomedical optics express · 2020Article
- Imaging in the repair of peripheral nerve injury.Nanomedicine (London, England) · 2019Article
- Toward optimization of blood brain barrier opening induced by laser-activated perfluorocarbon nanodroplets.Biomedical optics express · 2019Article
- Leveraging the Imaging Transmit Pulse to Manipulate Phase-Change Nanodroplets for Contrast-Enhanced Ultrasound.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A major obstacle in the monitoring and treatment of neurological diseases is the blood brain barrier (BBB), a semipermeable barrier that prevents the delivery of many therapeutics and imaging contrast agents to the brain. In this work, we explored the possibility of laser-activated perfluorocarbon nanodroplets (PFCnDs) to open the BBB and deliver agents to the brain tissue. Specifically, near infrared (NIR) dye-loaded PFCnDs comprised of a perfluorocarbon (PFC) core with a boiling point above physiological temperature were repeatedly vaporized and recondensed from liquid droplet to gas bubble under pulsed laser excitation. As a result, this pulse-to-pulse repeated behavior enabled the recurring interaction of PFCnDs with the endothelial lining of the BBB, allowing for a BBB opening and extravasation of dye into the brain tissue. The blood brain barrier opening and delivery of agents to tissue was confirmed on the macro and the molecular level by evaluating Evans Blue staining, ultrasound-guided photoacoustic (USPA) imaging, and histological tissue analysis. The demonstrated PFCnD-assisted pulsed laser method for BBB opening, therefore, represents a tool that has the potential to enable non-invasive, cost-effective, and efficient image-guided delivery of contrast and therapeutic agents to the brain.
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Registered trials
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