Evidence map›Paper›PMID 30615644›Full record

SynthesisPloS one2019

Prevalence of Chagas disease in Colombia: A systematic review and meta-analysis.

Mario J Olivera, Johana A Fory, Julián F Porras, Giancarlo Buitrago

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Species Typing of Trypanosomatids Using Amplicon-Based Sequencing.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  6. Article
  7. Clinical Progression of Cardiac ChronicPathogens (Basel, Switzerland) · 2025
    Article
  8. Review
  9. Article
  10. Article
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  12. Multilocus genetic analysis ofParasite epidemiology and control · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Frontiers in molecular biosciences · 2023
    Article
  17. Article
  18. Observational
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Mario J OliveraGrupo de Parasitología, Instituto Nacional de Salud, Bogotá, D.C., Colombia.ORCID 0000-0002-6885-6353
Johana A ForyFacultad de Medicina, Universidad Militar Nueva Granada, Bogotá, D.C., Colombia.
Julián F PorrasFacultad de Medicina, Universidad Nacional de Colombia, Bogotá, D.C., Colombia.ORCID 0000-0003-1861-4601
Giancarlo BuitragoDepartamento de Epidemiología y Bioestadística, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.ORCID 0000-0002-7466-8244
Pontificia Universidad Javeriana · COMilitary University Nueva Granada · COUniversidad Nacional de Colombia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite the adoption of campaigns to interrupt the main vector and to detect Trypanosoma cruzi in blood banks, millions of people are still chronically infected; however, the prevalence data are limited, and the epidemiology of Chagas disease has not been systematically evaluated. This study aimed to estimate the prevalence of Chagas disease in Colombia.

methodsA systematic literature review and meta-analysis was conducted to select all observational studies reporting the prevalence of Chagas disease in Colombia, based on serological diagnosis in participants of any age and published between January 2007 and November 2017. Pooled estimates and 95% confidence intervals (95% CIs) were calculated using random-effects models. In addition, the I2 statistic was calculated.

resultsThe literature search yielded a total of 1,510 studies; sixteen articles with relevant prevalence data were included in the systematic review. Of these, only 12 articles were included for entry in the meta-analysis. The pooled prevalence of Chagas disease across studies was 2.0% (95% CI: 1.0-4.0). A high degree of heterogeneity was found among studies (I2 > 75%; p < 0.001). The publication bias was not statistically significant (Egger's test, p = 0.078). The highest pooled prevalences were found in the adult population (3.0%, 95% CI: 1.0-4.0), pregnant women (3.0%, 95% CI: 3.0-4.0) and the Orinoco region (7.0%, 95% CI: 2.2-12.6).

conclusionsThe results indicate that the T. cruzi-infected population is aging, the adult population, pregnant women and that the Orinoco region (department of Casanare) have the highest prevalences. These results highlight the need to maintain screening and surveillance programs to identify people with chronic T. cruzi infections.

Indexed as

Disease VectorsAnimalsChagas DiseaseChronic DiseaseColombiaFemaleHealth Services Needs and DemandHumansMass ScreeningPregnancyPregnancy Complications, ParasiticPrevalenceTrypanosoma cruzi

Identifiers

PMID30615644
PMCPMC6322748
OpenAlexW2910431422

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.