ArticleJournal of biomedical materials research. Part A2019
Polymer scaffold architecture is a key determinant in mast cell inflammatory and angiogenic responses.
Article in Journal of biomedical materials research. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
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- Advances in Nanomedicine and Biomaterials for Endometrial Regeneration: A Comprehensive Review.International journal of nanomedicine · 2024Review
- Tissue engineering modalities in skeletal muscles: focus on angiogenesis and immunomodulation properties.Stem cell research & therapy · 2023Review
- Modulation of Macrophage Function by Bioactive Wound Dressings with an Emphasis on Extracellular Matrix-Based Scaffolds and Nanofibrous Composites.Pharmaceutics · 2023Review
- Immunomodulatory Biomaterials and Emerging Analytical Techniques for Probing the Immune Micro-Environment.Tissue engineering and regenerative medicine · 2023Review
- Correction of large jawbone defect in the mouse using immature osteoblast-like cells and a 3D polylactic acid scaffold.PNAS nexus · 2022Article
- Evaluation of Polycaprolactone Electrospun Nanofiber-Composites for Artificial Skin Based on Dermal Fibroblast Culture.Bioengineering (Basel, Switzerland) · 2022Article
- The Emerging Role of Immune Cells and Targeted Therapeutic Strategies in Diabetic Wounds Healing.Journal of inflammation research · 2022Review
- Cell-Seeded Biomaterial Scaffolds: The Urgent Need for Unanswered Accelerated Angiogenesis.International journal of nanomedicine · 2022Review
- Mast Cell-Biomaterial Interactions and Tissue Repair.Tissue engineering. Part B, Reviews · 2021Review
- Control of innate immune response by biomaterial surface topography, energy, and stiffness.Acta biomaterialia · 2021Review
- Electrospun Fibres with Hyaluronic Acid-Chitosan Nanoparticles Produced by a Portable Device.Nanomaterials (Basel, Switzerland) · 2020Article
- Electrospun Nanofibers for Improved Angiogenesis: Promises for Tissue Engineering Applications.Nanomaterials (Basel, Switzerland) · 2020Review
- TNF-α and INF-γ primed canine stem cell-derived extracellular vesicles alleviate experimental murine colitis.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Implanted polymer scaffolds can induce inflammation leading to the foreign body response (FBR), fibrosis, and implant failure. Thus, it is important to understand how immune cells interact with scaffolds to mitigate inflammation and promote a regenerative response. We previously demonstrated that macrophage phenotype is modulated by fiber and pore diameters of an electrospun scaffold. However, it is unclear if this effect is consistent among other innate immune cells. Mast cells are inflammatory sentinels that play a vital role in the FBR of implanted biomaterials, as well as angiogenesis. We determined if altering electrospun scaffold architecture modulates mast cell responses, with the goal of promoting regenerative cell-scaffold interactions. Polydioxanone (PDO) scaffolds were made from 60 mg/mL or 140 mg/mL PDO solutions, yielding structures with divergent fiber and pore diameters. Mouse mast cells plated on these scaffolds were activated with IL-33 or lipopolysaccharide (LPS). Relative to the 60 mg/mL scaffold, 140 mg/mL scaffolds yielded less IL-6 and TNF, and greater VEGF secretion. Pores >4-6 μm elicited less IL-6 and TNF secretion. IL-33-induced VEGF regulation was more complex, showing effects of both pore size and fiber diameter. These data indicate parameters that can predict mast cell responses to scaffolds, informing biomaterial design to increase wound healing and diminish implant rejection. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 884-892, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.