ArticleMagnetic resonance in medicine2019
Association of bone mineral density and fat fraction with magnetic susceptibility in inflamed trabecular bone.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Toward a realistic in silico abdominal phantom for QSM.Magnetic resonance in medicine · 2023Article
- Investigating the effect of oblique image acquisition on the accuracy of QSM and a robust tilt correction method.Magnetic resonance in medicine · 2023Article
- Quantifying calcium changes in the fetal spine using quantitative susceptibility mapping as extracted from STAGE imaging.European radiology · 2023Article
- Chemical Shift-Encoded MRI of Bone Metabolic Markers in Ankylosing Spondylitis.Disease markers · 2022Article
- Association of bone mineral density and fat fraction with magnetic susceptibility in inflamed trabecular bone.Magnetic resonance in medicine · 2019Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo evaluate the relationship between bone mineral density (BMD) and magnetic susceptibility, and between proton density fat fraction and susceptibility, in inflamed trabecular bone.
methodsTwo different phantoms modeling the fat fraction (FF) and BMD values of healthy bone marrow and disease states were scanned using a multiecho gradient echo acquisition at 3T. After correction for fat-water chemical shift, susceptibility mapping was performed, and susceptibility measurements were compared with BMD and FF values using linear regression. Patients with spondyloarthritis were scanned using the same protocol, and susceptibility values were calculated in areas of inflamed bone (edema) and fat metaplasia, both before and after accounting for the contribution of fat to the total susceptibility.
resultsSusceptibility values in the phantoms were accurately described by a 2D linear function, with a negative correlation between BMD and susceptibility and a positive correlation between FF and susceptibility (adjusted R
conclusionsBMD and proton density fat fraction both influence the total susceptibility of bone marrow and failure to account for the fat contribution could lead to errors in BMD quantification. We propose a method for removing the fat contribution from the total susceptibility, based on the observed linear relationship between susceptibility and FF. In inflamed bone, the overall increase in susceptibility in areas of fat metaplasia is at least partly due to increased fat content.
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