ArticleThe Journal of physiology2019
Fasting enhances cold resistance in fish through stimulating lipid catabolism and autophagy.
Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 137 citations in OpenAlex.
- Starvation Exacerbates Cold-Induced Synergistic Hepatic Injury inAntioxidants (Basel, Switzerland) · 2026Article
- Cold acclimation promotes the fatty acid desaturation and glycerophospholipid metabolism of the visceral adipose tissue in the Schizothorax prenanti.Fish physiology and biochemistry · 2026Article
- Fasting influences the muscle quality of fish during transportation by regulating the balance between energy metabolism and ammonia nitrogen stress.Journal of advanced research · 2026Article
- Physiological Responses to Thermal Stress in the Liver ofAnimals : an open access journal from MDPI · 2025Article
- Low-Temperature Stress-Induced Hepatic Injury in Darkbarbel Catfish (Antioxidants (Basel, Switzerland) · 2025Article
- Metabolomics-Based Analysis of Adaptive Mechanism ofAnimals : an open access journal from MDPI · 2025Article
- Physiological Traits for Predicting Poleward Extensions in Tropical Fishes: From Lab to Management.Global change biology · 2025Review
- Chromosome-Level Genome Assembly and Comparative Transcriptome Analyses Identified Energy Conservation as a Key Strategy for Anadromous Adaptation of the Hilsa Shad,Biomolecules · 2025Article
- The Effect of 7-Day Cold Water Acclimation on Autophagic and Apoptotic Responses in Young Males.Advanced biology · 2025Article
- Protective multi-stressor interactions in the Anthropocene: Key considerations for investigating cross-tolerance in a conservation context.Conservation physiology · 2025Article
- Effects of dietary methionine on the growth and protein synthesis of juvenile Chinese mitten crabs (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Whether hypoxia tolerance improved after short-term fasting is closely related to phylogeny but not to foraging mode in freshwater fish species.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Influence of Starvation on Biochemical, Physiological, Morphological, and Transcriptional Responses Associated with Glucose and Lipid Metabolism in the Liver of Javelin Goby (Animals : an open access journal from MDPI · 2024Article
- The preferential utilization of hepatic glycogen as energy substrates in largemouth bass (Micropterus salmoides) under short-term starvation.Fish physiology and biochemistry · 2024Article
- Zebrafish Feed Intake: A Systematic Review for Standardizing Feeding Management in Laboratory Conditions.Biology · 2024Review
- Mitigation of cold stress in Nile tilapia (Oreochromis niloticus) through dietary lipids supplementation: a preliminary network meta-analysis.Fish physiology and biochemistry · 2024Review
- Characterization of threeFrontiers in physiology · 2024Article
- Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish.The Journal of biological chemistry · 2023Article
- Hypoxia tolerance in fish depends on catabolic preference between lipids and carbohydrates.Zoological research · 2023Article
- Dietary restriction to optimize T cell immunity is an ancient survival strategy conserved in vertebrate evolution.Cellular and molecular life sciences : CMLS · 2023Article
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsIn a cold environment, mammals increase their food intake while fish decrease or stop feeding. However, the physiological value of fasting during cold resistance in fish is currently unknown. Fasting for more than 48 h enhanced acute cold resistance in zebrafish, which correlated with lipid catabolism and cell damage attenuation. Lipid catabolism and autophagy were necessary for cold resistance in fish and the inhibition of mitochondrial fatty acid β-oxidation or autophagy weakened the fasting-induced cold resistance. Repression of mechanistic target of rapamycin (mTOR) signalling pathway by rapamycin largely mimicked the beneficial effects of fasting in promoting cold resistance, suggesting mTOR signalling may be involved in the fasting-induced cold resistance in fish. Our study demonstrates that fasting may be a protective strategy for fish to survive under cold stress. ABSTRACT: In cold environments, most homeothermic animals increase their food intake to supply more energy to maintain body temperature, whereas most poikilothermic animals such as fishes decrease or even stop feeding under cold stress. However, the physiological value of fasting during cold resistance in poikilotherms has not been explained. Here, we show that moderate fasting largely enhanced cold resistance in fish. By using pharmacological (fenofibrate, mildronate, chloroquine and rapamycin) and nutritional approaches (fatty acids diets and amino acids diets) in wild-type or specific gene knock-out zebrafish models (carnitine palmitoyltransferase-1b-deficient strain, CPT1b
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.