Evidence map›Paper›PMID 30615138›Full record

ReviewNeuro-oncology2019

PET imaging in patients with brain metastasis-report of the RANO/PET group.

Norbert Galldiks, Karl-Josef Langen, Nathalie L Albert, Marc Chamberlain, Riccardo Soffietti, Michelle M Kim, Ian Law, Emilie Le Rhun, Susan Chang, Julian Schwarting and 6 more

Abstract readReview
In one paragraph

Review in Neuro-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Pooled it
  5. Trial
  6. Trial
  7. World journal of nuclear medicine · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Preclinical Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Imaging in Neuro-oncology.Seminars in neurology · 2025
    Review
  18. Review
  19. Hybrid [AJNR. American journal of neuroradiology · 2025
    Article
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Norbert GalldiksDepartment of Neurology, University Hospital Cologne, Cologne, Germany.
Karl-Josef LangenInstitute of Neuroscience and Medicine 3, 4, Research Center Juelich, Juelich, Germany.
Nathalie L AlbertDepartment of Nuclear Medicine, Ludwig Maximilians-University of Munich, Munich, Germany.
Marc ChamberlainDepartments of Neurology and Neurological Surgery, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, USA.
Riccardo SoffiettiDepartment of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy.
Michelle M KimDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.
Ian LawDepartment of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Denmark.
Emilie Le RhunDepartment of Neurosurgery, University Hospital Lille, Lille, France.
Susan ChangDepartment of Neurosurgery, University of California, San Francisco, California, USA.
Julian SchwartingDepartment of Neurosurgery, Ludwig Maximilians-University of Munich, Munich, Germany.
Stephanie E CombsDepartment of Radiation Oncology, Technical University Munich, Munich, Germany.
Matthias PreusserDepartment of Medicine I and Comprehensive Cancer Centre CNS Tumours Unit, Medical University of Vienna, Vienna, Austria.
Peter ForsythMoffitt Cancer Center, University of South Florida, Tampa, Florida, USA.
Whitney PopeDepartment of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, California , USA.
Michael WellerDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
Jörg C TonnDepartment of Neurosurgery, Ludwig Maximilians-University of Munich, Munich, Germany.

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Brain metastases (BM) from extracranial cancer are associated with significant morbidity and mortality. Effective local treatment options are stereotactic radiotherapy, including radiosurgery or fractionated external beam radiotherapy, and surgical resection. The use of systemic treatment for intracranial disease control also is improving. BM diagnosis, treatment planning, and follow-up is most often based on contrast-enhanced magnetic resonance imaging (MRI). However, anatomic imaging modalities including standard MRI have limitations in accurately characterizing posttherapeutic reactive changes and treatment response. Molecular imaging techniques such as positron emission tomography (PET) characterize specific metabolic and cellular features of metastases, potentially providing clinically relevant information supplementing anatomic MRI. Here, the Response Assessment in Neuro-Oncology working group provides recommendations for the use of PET imaging in the clinical management of patients with BM based on evidence from studies validated by histology and/or clinical outcome.

Indexed as

AnimalsBrain NeoplasmsHumansMolecular ImagingPositron-Emission TomographyRadiopharmaceuticalsRadiopharmaceuticalsamino acid PETbrain metastasesFDG PETFETpseudoprogression

Identifiers

PMID30615138
PMCPMC6502495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.