ArticleCerebral cortex (New York, N.Y. : 1991)2019
Enhanced Population Coding for Rewarded Choices in the Medial Frontal Cortex of the Mouse.
Article in Cerebral cortex (New York, N.Y. : 1991), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Cortex-wide characterization of decision-making neural dynamics during spatial navigation.Nature communications · 2026Article
- Anterior cingulate neurons combine outcome monitoring of past decisions with ongoing movement signals.Nature communications · 2026Article
- Neural circuit models for evidence accumulation through choice-selective sequences.Nature communications · 2026Article
- Autism-associatedProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.Science advances · 2025Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.bioRxiv : the preprint server for biology · 2024Article
- Trial-history biases in evidence accumulation can give rise to apparent lapses in decision-making.Nature communications · 2024Article
- Distributed processing for value-based choice by prelimbic circuits targeting anterior-posterior dorsal striatal subregions in male mice.Nature communications · 2023Article
- Influence of Recent Trial History on Interval Timing.Neuroscience bulletin · 2023Article
- Trial-history biases in evidence accumulation can give rise to apparent lapses.bioRxiv : the preprint server for biology · 2023Article
- Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning.Cell reports · 2022Article
- Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment.Nature communications · 2022Article
- Dimensionality reduction and recurrence analysis reveal hidden structures of striatal pathological states.Frontiers in systems neuroscience · 2022Article
- Stress induces microglia-associated synaptic circuit alterations in the dorsomedial prefrontal cortex.Neurobiology of stress · 2021Article
- Beyond the hippocampus: The role of parahippocampal-prefrontal communication in context-modulated behavior.Neurobiology of learning and memory · 2021Review
- Coherent theta activity in the medial and orbital frontal cortices encodes reward value.eLife · 2021Article
- Prefrontal deep projection neurons enable cognitive flexibility via persistent feedback monitoring.Cell · 2021Article
- Dynamic patterns of correlated activity in the prefrontal cortex encode information about social behavior.PLoS biology · 2021Article
- Identification and quantification of neuronal ensembles in optical imaging experiments.Journal of neuroscience methods · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Instrumental behavior is characterized by the selection of actions based on the degree to which they lead to a desired outcome. However, we lack a detailed understanding of how rewarded actions are reinforced and preferentially implemented. In rodents, the medial frontal cortex is hypothesized to play an important role in this process, based in part on its capacity to encode chosen actions and their outcomes. We therefore asked how neural representations of choice and outcome might interact to facilitate instrumental behavior. To investigate this question, we imaged neural ensemble activity in layer 2/3 of the secondary motor region (M2) while mice engaged in a two-choice auditory discrimination task with probabilistic outcomes. Correct choices could result in one of three reward amounts (single, double or omitted reward), which allowed us to measure neural and behavioral effects of reward magnitude, as well as its categorical presence or absence. Single-unit and population decoding analyses revealed a consistent influence of outcome on choice signals in M2. Specifically, rewarded choices were more robustly encoded relative to unrewarded choices, with little dependence on the exact magnitude of reinforcement. Our results provide insight into the integration of past choices and outcomes in the rodent brain during instrumental behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.