Evidence map›Paper›PMID 30614634›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

Survival benefit of accepting livers from deceased donors over 70 years old.

Christine E Haugen, Mary G Bowring, Courtenay M Holscher, Kyle R Jackson, Jacqueline Garonzik-Wang, Andrew M Cameron, Benjamin Philosophe, Mara McAdams-DeMarco, Dorry L Segev

Abstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Survival benefit of accepting kidneys from older donation after cardiac death donors.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Christine E HaugenDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-5884-2604
Mary G BowringDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7299-7730
Courtenay M HolscherDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-5808-5954
Kyle R JacksonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-8135-5377
Jacqueline Garonzik-WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Andrew M CameronDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Benjamin PhilosopheDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Mara McAdams-DeMarcoDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0003-3013-925X
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Funding

Kidney transplantation in older, frail and cognitively impaired adults with ESRD: Balancing utility vs. justiceR01AG055781 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2017 to 2021
$4.2M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Frailty and Adverse Health Outcomes of Aging in Older Adults with Kidney FailureK01AG043501 · NIA · JOHNS HOPKINS UNIVERSITY · PI MCADAMS DEMARCO, MARA A. · 2014 to 2018
$624k
Differential Survival Benefit of Incompatible Living Donor Kidney Transplantation: Modeling Outcomes for Different Patient PhenotypesF32DK113719 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JACKSON, KYLE R · 2017 to 2019
$238k
Trajectory of post-donation renal function in living kidney donorsF32DK109662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HOLSCHER, COURTENAY · 2016 to 2018
$232k
Novel Frailty Phenotype in Older Adults with End-Stage Renal DiseaseF32AG053025 · NIA · JOHNS HOPKINS UNIVERSITY · PI HAUGEN, CHRISTINE · 2016 to 2019
$204k
NIAID NIH HHS K24 AI144954NIA NIH HHS F32 AG053025NIA NIH HHS K01 AG043501NIA NIH HHS R01 AG055781NIDDK NIH HHS F32 DK109662NIDDK NIH HHS F32 DK113719NIDDK NIH HHS K24 DK101828
6 · The paper itself

Abstract

Livers from older donors (OLDs; age ≥70) are risky and often declined; however, it is likely that some candidates will benefit from OLDs versus waiting for younger ones. To characterize the survival benefit of accepting OLD grafts, we used 2009-2017 SRTR data to identify 24 431 adult liver transplant (LT) candidates who were offered OLD grafts eventually accepted by someone. Outcomes from the time-of-offer were compared between candidates who accepted an OLD graft and matched controls within MELD ± 2 who declined the same offer. Candidates who accepted OLD grafts (n = 1311) were older (60.5 vs. 57.8 years, P < .001), had a higher median MELD score (25 vs. 22, P < .001), and were less likely to have hepatitis C cirrhosis (14.9% vs. 31.2%, P < .001). Five-year cumulative mortality among those who accepted versus declined the same OLD offer was 23.4% versus 41.2% (P < .001). Candidates who accepted OLDs experienced an almost twofold reduction in mortality (aHR:

Indexed as

Donor SelectionGraft SurvivalAgedAged, 80 and overAge FactorsCadaverEnd Stage Liver DiseaseFemaleFollow-Up StudiesHumansLiver TransplantationMaleMiddle AgedPrognosisRegistriesSurvival Rateclinical research/practicedonors and donation: deceaseddonors and donation: extended criterialiver transplantation/hepatologyorgan acceptanceScientific Registry for Transplant Recipients (SRTR)

Identifiers

PMID30614634
PMCPMC6591042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.