Evidence map›Paper›PMID 30614626›Full record

ArticlePigment cell & melanoma research2019

Notch signaling activation induces cell death in MAPKi-resistant melanoma cells.

Dareen M Mikheil, Kirthana Prabhakar, Ayyan Arshad, Carlos I Rodriguez, Michael A Newton, Vijayasaradhi Setaluri

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pigment cell & melanoma research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dareen M MikheilComparative Biomedical Sciences Graduate Program, University of Wisconsin, Madison, Wisconsin.
Kirthana PrabhakarDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin.
Ayyan ArshadDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin.
Carlos I RodriguezDepartment of Dermatology, University of Wisconsin, Madison, Wisconsin.
Michael A NewtonDepartment of Biostatistics & Medical Informatics, University of Wisconsin, Madison, Wisconsin.
Vijayasaradhi SetaluriComparative Biomedical Sciences Graduate Program, University of Wisconsin, Madison, Wisconsin.ORCID 0000-0001-6468-7663
University of Wisconsin–Madison · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
TrainingU54AI117924 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CRAVEN, MARK W. · 2014 to 2018
$11.3M
Skin Diseases Research Center at the University of WisconsinP30AR066524 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI LONGLEY, B JACK · 2014 to 2018
$2.6M
Prognostic Significance of Neuronal Differentiation of Cutaneous MelanomaR21CA125091 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI SETALURI, VIJAYASARADHI · 2008 to 2009
$364k
Role of Notch Signaling in Melanoma Transdifferentiation and Tumor ProgressionI01BX002623 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI SETALURI, VIJAYASARADHI · 2015 to 2019
–
BLRD VA I01 BX002623NCI NIH HHS P30 CA014520NCI NIH HHS P30CA014520NCI NIH HHS R21 CA125091NIAID NIH HHS U54 AI117924NIAMS NIH HHS P30 AR066524NIH HHS U54AI117924VA 1ǀ01BX002623
6 · The paper itself

Abstract

The role of Notch signaling in melanoma drug resistance is not well understood. In this study, we show that although NOTCH proteins are upregulated in metastatic melanoma cell lines, Notch signaling inhibition had no effect on cell survival, growth, migration or the sensitivity of BRAFV600E-melanoma cells to MAPK inhibition (MAPKi). We found that NOTCH1 is downregulated in melanoma cell lines with intrinsic and acquired resistance to MAPKi. Forced expression of NICD1, the active form of Notch1, caused apoptosis of the NOTCH

Indexed as

Signal TransductionApoptosisCell DeathCell Line, TumorDown-RegulationDrug Resistance, NeoplasmEndothelin-1Gene Expression Regulation, NeoplasticHumansLigandsMelanomaMitogen-Activated Protein KinasesMutationProtein Kinase InhibitorsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-junBRAF protein, humanEndothelin-1HES1 protein, humanLigandsMitogen-Activated Protein KinasesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-junReceptors, NotchTranscription Factor HES-1apoptosisBRAFV600Ecutaneous melanomadrug resistanceEDN1Notch

Identifiers

PMID30614626
PMCPMC6581614
OpenAlexW2908565019

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.