Evidence map›Paper›PMID 30614572›Full record

ArticleJournal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie2019

A certain invariance property of BLUE in a whole-genome regression context.

Daniel Gianola, Rohan L Fernando, Dorian J Garrick

Abstract read
In one paragraph

Article in Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. A certain invariance property of BLUE in a whole-genome regression context.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel GianolaDepartment of Animal Science, Iowa State University, Ames, Iowa.ORCID https://orcid.org/0000-0001-8217-2348
Rohan L FernandoDepartments of Animal Sciences and Dairy Science, University of Wisconsin-Madison, Madison, Wisconsin.ORCID https://orcid.org/0000-0001-5821-099X
Dorian J GarrickAL Rae Centre of Genetics and Breeding, Massey University, Palmerston North, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A curious result from mixed linear models applied to genome-wide association studies was expanded. In particular, a model in which one or more markers are considered as fixed but are allowed to contribute to the covariance structure by treating such markers as random as well was examined. The best linear unbiased estimator of marker effects is invariant with respect to whether those markers are employed in constructing a genomic relationship matrix or are ignored, provided marker effects are uncorrelated with those not being tested. Also, the implications of regarding some marker effects as fixed when, in fact, these possess a non-trivial covariance structure with those declared as random were examined.

Indexed as

Linear ModelsModels, GeneticModels, StatisticalAnimalsBreedingGenomeGenome-Wide Association StudyGenomicsPolymorphism, Single Nucleotide

Identifiers

PMID30614572
PMCPMC6850311

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.