ArticleMedical science monitor : international medical journal of experimental and clinical research2019
Risk Factors Affecting Patterns of Antibiotic Resistance and Treatment Efficacy in Extreme Drug Resistance in Intensive Care Unit-Acquired Klebsiella Pneumoniae Infections: A 5-Year Analysis.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 25 citations in OpenAlex.
- Colistin Resistance in Critically Ill Adults: A Systematic Review of Epidemiological, Clinical, Laboratory, and Molecular Evidence.Microorganisms · 2026Review
- Susceptibility Patterns and Factors Associated with Multidrug Antibiotic Resistance Among Patients with Productive Cough in Southwestern Uganda.Infection and drug resistance · 2026Article
- Clinical Distribution Characteristics and Antimicrobial Resistance Trends ofInfection and drug resistance · 2026Article
- Antibiotic resistance inFrontiers in microbiology · 2026Review
- Fluorinated Rh(I)-NHC Compounds as Potential Antibacterials Against Multidrug-ResistantPharmaceutics · 2025Article
- Clinical Outcomes and Mortality Predictors of Klebsiella Pneumoniae Pneumonia in Vietnamese Elderly: a Prospective Cohort Study.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Similarity Analysis ofAntibiotics (Basel, Switzerland) · 2023Article
- The importance of active surveillance of carbapenem-resistant Enterobacterales (CRE) in colonization rates in critically ill patients.PloS one · 2022Article
- Global Prevalence of Nosocomial Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2021Review
- Antibiotic resistance among the Lahu hill tribe people, northern Thailand: a cross-sectional study.BMC infectious diseases · 2021Article
- Time to blood, respiratory and urine culture positivity in the intensive care unit: Implications for de-escalation.SAGE open medicine · 2021Article
- High Prevalence of Antimicrobial Resistance Among Gram-Negative Isolated Bacilli in Intensive Care Units at a Tertiary-Care Hospital in Yucatán Mexico.Medicina (Kaunas, Lithuania) · 2019Article
- Antimicrobial resistance and risk factors for mortality of pneumonia caused byInfection and drug resistance · 2019Article
- Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme.Signal transduction and targeted therapyArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND We investigated the factors affecting antibiotic resistance in the intensive care unit (ICU)-related hospital-acquired infections caused by Klebsiella pneumoniae (KP-HAI) and the effects of antibiotics used for high-level antibiotic resistance on patient survival. MATERIAL AND METHODS This retrospective study was performed at the adult ICU of Bezmialem Vakif University Hospital. Patients who were followed up between 01 January 2012 and 31 May 2017 were evaluated. Each KP strain was categorized according to resistance patterns and analyzed. The efficiency of antibiotic therapy for highly-resistant KP-HAI was determined by patients' lifespans. RESULTS We evaluated 208 patients. With the prior use of carbapenem, antibiotics against resistant Gram-positives, and tigecycline, it was observed that the resistance rate of the infectious agents had a significant increase. As the resistance category increases, a significant decrease was seen in the survival time. We observed that if the treatment combination included trimethoprim-sulfamethoxazole, the survival time became significantly longer, and tigecycline-carbapenem-colistin and tigecycline-carbapenem combination patients showed significantly shorter survival times. CONCLUSIONS When the resistance increases, delays will occur in starting suitable and effective antibiotic treatment, with increased sepsis frequency and higher mortality rates. Trimethoprim-sulfamethoxazole can be an efficient alternative to extend survival time in trimethoprim-sulfamethoxazole-susceptible KP infections that have extensive drug resistance.
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