Trial reportPediatric pulmonology2019
Children with poorly controlled asthma: Randomized controlled trial of a home-based environmental control intervention.
Trial report in Pediatric pulmonology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Update of a systematic review on associations between environmental exposures and asthma control and exacerbations in young children.BMJ open · 2025Pooled it
- Social Risk Interventions and Health Care Utilization for Pediatric Asthma: A Systematic Review and Meta-analysis.JAMA pediatrics · 2022Pooled it
- Effectiveness of Caregiver Interventions to Reduce Household Secondhand Smoke Exposure on Pediatric Asthma Outcomes: A Systematic Review.Pediatric allergy, immunology, and pulmonologyPooled it
- Psychometric evaluation of the medication adherence report scale in caregivers of low-income, urban, African American children with poorly controlled asthma.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Trial
- Persistent exposure to second-hand smoke and asthma endotypes in a study of Puerto Rican youth.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Evaluation of a Program to Reduce Home Environment Risks for Children with Asthma Residing in Urban Areas.International journal of environmental research and public health · 2021Article
- Associations among neighborhood greenspace, neighborhood violence, and children's asthma control in an urban city.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Impact of family socioeconomic position on childhood asthma outcomes, severity, and specialist referral - a Danish nationwide study.Chronic respiratory diseaseArticle
Corrections and comments
- Erratum issuedCorrigendum.2020
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundFew trials have tested targeted environmental control (EC) interventions based on biomarkers of second hand smoke (SHS) exposure and allergen sensitization in reducing asthma emergency department (ED) visits in children with poorly controlled asthma.
methodsOverall, 222 children with poorly controlled asthma were randomized into a home-based EC intervention (INT) or control (CON) group and followed for ED visits over 12 months. All children received allergen-specific IgE serologic testing and SHS exposure biomarker testing to inform the EC intervention. Pharmacy data was examined for asthma medication fills. Cox proportional hazards and multivariate regression models were performed to examine factors associated with repeat ED visits.
resultsThere was no difference in increased risk of >1 ED visit at 12 months between INT and CON groups. Most children (75%) had moderate/severe persistent asthma. Over half (56%) had SHS exposure and 83% tested positive for >1 allergen sensitization. Among children without SHS exposure, the median time to first recurrent ED visit differed by group (CON: 195; INT: >365 days) after adjusting for child age, allergic sensitization, medication fills prior to baseline, controller medication use, and the interaction between group status and SHS exposure. Children who had positive allergic sensitizations, younger, had increased controller medication use and randomized to the CON group and had no SHS exposure had increased risk for a repeat ED visit over 12 months.
conclusionsIn this study, a home-based EC intervention was not successful in reducing asthma ED revisits in children with poorly controlled asthma with SHS exposure. Allergic sensitization, young age, and increased controller medication use were important predictors of asthma ED visits.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.