ReviewThe European journal of neuroscience2020
Sleep and synaptic down-selection.
Review in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
92 citing papers in PubMed.
- Modulation of early non-rapid eye movement slow wave activity by ketamine in treatment-resistant depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Does sleep matter for recovery after stroke? Functional severity shapes the association between sleep and functional outcome during inpatient stroke rehabilitation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Overnight sleep features and next-morning brain metabolism in older adults.Sleep medicine · 2026Article
- Induction of cortical on/off periods in awake mice fulfills sleep functions.Nature neuroscience · 2026Article
- Molecular Signatures of Ferroptosis in Sleep Disorders: A Comparative Analysis of GPX4, ACSL4, and TfR1.Molecular neurobiology · 2026Article
- Active zone plasticity couples sleep need to presynaptic hypophosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Sleep deprivation and memory: A neurobiological perspective.IBRO neuroscience reports · 2026Article
- The bidirectional relationship between epilepsy and sleep: a narrative review.Frontiers in neurology · 2026Review
- Contributions of Zebrafish to Our Understanding of the Function and Regulation of Sleep.Current sleep medicine reports · 2026Review
- Abnormal local markers of sleep homeostasis in patients with focal epilepsy.Brain communications · 2026Article
- Refuting a Temporal Correlation: Interictal Epileptic Discharges Do Not Preferentially Occur During Respiratory Events in Patients With Sleep-Related Breathing Disorder and Epilepsy.Journal of sleep research · 2025Article
- Sleep Mediates the Association Between Emotion Dysregulation and Repetitive Behaviors in Autistic Children.Journal of autism and developmental disorders · 2025Article
- Induction of cortical ON/OFF periods in awake mice fulfills sleep functions.bioRxiv : the preprint server for biology · 2025Article
- Local versus global sleep organization and the quest to determine sleep function.Neurobiology of sleep and circadian rhythms · 2025Article
- The futuristic manifolds of REM sleep.Journal of sleep research · 2025Review
- Altered Muscle-Brain Connectivity During Left and Right Biceps Brachii Isometric Contraction Following Sleep Deprivation: Insights from PLV and PDC.Sensors (Basel, Switzerland) · 2025Article
- Sleep-wake-related changes in intracellular chloride regulate plasticity at glutamatergic cortical synapses.Current biology : CB · 2025Article
- Short naps improve subsequent learning in a high school setting.NPJ science of learning · 2025Article
- Review
- Does sleep benefit source memory? Investigating 12-h retention intervals with a multinomial modeling approach.Memory & cognition · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The synaptic homeostasis hypothesis (SHY) proposes that sleep is an essential process needed by the brain to maintain the total amount of synaptic strength under control. SHY predicts that by the end of a waking day the synaptic connections of many neural circuits undergo a net increase in synaptic strength due to ongoing learning, which is mainly mediated by synaptic potentiation. Stronger synapses require more energy and supplies and are prone to saturation, creating the need for synaptic renormalization. Such renormalization should mainly occur during sleep, when the brain is disconnected from the environment and neural circuits can be broadly reactivated off-line to undergo a systematic but specific synaptic down-selection. In short, according to SHY sleep is the price to pay for waking plasticity, to avoid runaway potentiation, decreased signal-to-noise ratio, and impaired learning due to saturation. In this review, we briefly discuss the rationale of the hypothesis and recent supportive ultrastructural evidence obtained in our laboratory. We then examine recent studies by other groups showing the causal role of cortical slow waves and hippocampal sharp waves/ripples in sleep-dependent down-selection of neural activity and synaptic strength. Finally, we discuss some of the molecular mechanisms that could mediate synaptic weakening during sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.