ArticleLasers in surgery and medicine2019
A miniaturized, tethered, spectrally-encoded confocal endomicroscopy capsule.
Article in Lasers in surgery and medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Endoluminal Procedures and Devices for Esophageal Tract Investigation: A Critical Review.Sensors (Basel, Switzerland) · 2023Pooled it
- Can artificial intelligence improve the diagnosis and management of patients with eosinophilic esophagitis?World journal of gastroenterology · 2025Review
- Biochemical detection of pediatric eosinophilic esophagitis using high wavenumber Raman endoscopy and stimulated Raman microscopy.Scientific reports · 2025Article
- In Vivo Raman Spectroscopy Reveals Biochemical Composition of the Esophageal Tissue in Pediatric Eosinophilic Esophagitis.Clinical and translational gastroenterology · 2024Article
- Advances in optical gastrointestinal endoscopy: a technical review.Molecular oncology · 2021Review
- Scattering-Based Light-Sheet Microscopy for Rapid Cellular Imaging of Fresh Tissue.Lasers in surgery and medicine · 2021Article
- Review
- Confocal laser endomicroscopy under propofol-based sedation for early gastric cancer and pre-cancerous lesions is associated with better diagnostic accuracy: a retrospective cohort study in China.BMC anesthesiology · 2021Article
- Novel Insights Into Tissue-Specific Biochemical Alterations in Pediatric Eosinophilic Esophagitis Using Raman Spectroscopy.Clinical and translational gastroenterology · 2020Observational
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveThe tethered spectrally-encoded confocal endomicroscopy (SECM) capsule is an imaging device that once swallowed by an unsedated patient can visualize cellular morphologic changes associated with gastrointestinal (GI) tract diseases in vivo. Recently, we demonstrated a tethered SECM capsule for counting esophageal eosinophils in patients with eosinophilic esophagitis (EoE) in vivo. Yet, the current tethered SECM capsule is far too long to be widely utilized for imaging pediatric patients, who constitute a major portion of the EoE patient population. In this paper, we present a new tethered SECM capsule that is 33% shorter, has an easier and repeatable fabrication process, and produces images with reduced speckle noise. MATERIALS AND
methodsThe smaller SECM capsule utilized a miniature condenser to increase the fiber numerical aperture and reduce the capsule length. A custom 3D-printed holder was developed to enable easy and repeatable device fabrication. A dual-clad fiber (DCF) was used to reduce speckle noise.
resultsThe fabricated SECM capsule (length = 20 mm; diameter = 7 mm) had a similar size and shape to a pediatric dietary supplement pill. The new capsule achieved optical sectioning thickness of 13.2 μm with a small performance variation between devices of 1.7 μm. Confocal images of human esophagus obtained in vivo showed the capability of this new device to clearly resolve microstructural epithelial details with reduced speckle noise.
conclusionsWe expect that the smaller size and better image performance of this new SECM capsule will greatly facilitate the clinical adoption of this technology in pediatric patients and will enable more accurate assessment of EoE-suspected tissues. Lasers Surg. Med. 51:452-458, 2019. © 2019 Wiley Periodicals, Inc.
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