ArticlePsychophysiology2019
Fear-potentiated startle response as an endophenotype: Evaluating metrics and methods for genetic applications.
Article in Psychophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Genetic and Environmental Influences on Fear Learning and Generalization.Psychophysiology · 2025Article
- Mapping 60 Years of Psychophysiology: A Bibliometric Analysis of Journal Performance, Authorship Trends, and Thematic Evolution.Psychophysiology · 2025Review
- Genetic and environmental influences on alpha amylase stress reactivity and shared genetic covariation with cortisol.Psychoneuroendocrinology · 2024Article
- Genetic and environmental influences on cortisol reactivity to a psychosocial stressor in adolescents and young adults.Psychoneuroendocrinology · 2021Article
- Mechanisms of False Alarm in Response to Fear Stimulus: An Event-Related Potential Study.Frontiers in human neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
The modulation of the startle response (SR) by threatening stimuli (fear-potentiated startle; FPS) is a proposed endophenotype for disorders of the fearful-fearlessness spectrum. FPS has failed to show evidence of heritability, raising concerns. However, metrics used to index FPS-and, importantly, other conditional phenotypes that are dependent on a baseline-may not be suitable for the approaches used in genetic epidemiology studies. Here, we evaluated multiple metrics of FPS in a population-based sample of preadolescent twins (N = 569 from 320 twin pairs, M
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.