Evidence map›Paper›PMID 30613865›Full record

ReviewPflugers Archiv : European journal of physiology2019

Visualizing the regulation of SLC34 proteins at the apical membrane.

Moshe Levi, Enrico Gratton

Abstract readReview
In one paragraph

Review in Pflugers Archiv : European journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Moshe LeviDepartment of Biochemistry and Molecular and Cellular Biology, Georgetown University, Washington, DC, USA. Moshe.Levi@georgetown.edu.ORCID 0000-0001-6403-2261
Enrico GrattonDepartment of Biomedical Engineering, Laboratory for Fluorescence Dynamics, University of California at Irvine, Irvine, CA, USA.
Fluor (United States) · USGeorgetown University · US

Funding

YEAST RIBOSOMAL STALK COMPOSITION IN VIVO BY TWO-PHOTON FCS AND PCH ANALYSISP41RR003155 · NCRR · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI GRATTON, ENRICO · 1986 to 2011
$14.9M
TRD4: Phasor analysisP41GM103540 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GRATTON, ENRICO · 2012 to 2020
$12.5M
Regulation of Renal Phosphate Transport by LipidsR01DK066029 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LEVI, MOSHE · 2005 to 2013
$3.2M
Role of FXR in Renal Disease of Metabolic Syndrome and AgingR01AG026529 · NIA · UNIVERSITY OF COLORADO DENVER · PI LEVI, MOSHE · 2007 to 2011
$1.8M
Renal Lipid Metabolism in Diabetic NephropathyR01DK062209 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LEVI, MOSHE · 2003 to 2006
$922k
Role of FXR and TGR5 in Age Related Renal DiseasesR01AG049493 · NIA · UNIVERSITY OF COLORADO DENVER · PI LEVI, MOSHE · 2016 to 2018
$917k
NCRR NIH HHS P41 RR003155NIA NIH HHS R01 AG026529NIA NIH HHS R01 AG049493NIDDK NIH HHS R01 DK062209NIDDK NIH HHS R01 DK066029NIGMS NIH HHS 2P41GM103540NIGMS NIH HHS P41 GM103540
6 · The paper itself

Abstract

The cloning of the renal NaPi-2a (SLC34A1) and NaPi-2c (SLC34A3) phosphate transporters has made it possible to characterize the molecular and biophysical regulation of renal proximal tubular reabsorption of inorganic phosphate (Pi). Dietary factors, such as Pi and K, and several hormones and phosphatonins, including parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and glucocorticoids, regulate the transporters through various transcriptional, translational, and post-translational mechanisms that involve acute trafficking via endocytosis or exocytosis, interactions with PDZ domain proteins, lipid microdomains, and diffusion and clustering in the apical brush border membrane. The visualization of these trafficking events by means of novel microscopy techniques that includes fluorescence lifetime imaging microscopy (FLIM), Förster resonance energy transfer (FRET), fluctuation correlation spectroscopy (FCS), and modulation tracking (MT), is the primary focus of this review.

Indexed as

AnimalsCell MembraneFibroblast Growth Factor-23HumansKidney Tubules, ProximalPhosphatesProtein TransportSodium-Phosphate Cotransporter Proteins, Type IIFGF23 protein, humanFibroblast Growth Factor-23PhosphatesSodium-Phosphate Cotransporter Proteins, Type IIFluctuation correlation spectroscopy (FCS)Fluorescence lifetime imaging microscopy (FLIM)Förster resonance energy transfer (FRET)NaPi-lipid interactionsNaPi-PDZ protein interactionsNaPi transporter diffusion and clustering

Identifiers

PMID30613865
PMCPMC6436987
OpenAlexW2907607755

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.