Evidence map›Paper›PMID 30613820›Full record

ArticleACS omega2018

Pharmacophore Modeling, Synthesis, and Antibacterial Evaluation of Chalcones and Derivatives.

Mingming Zhang, Allan M Prior, Marcus M Maddox, Wan-Jou Shen, Kirk E Hevener, David F Bruhn, Robin B Lee, Aman P Singh, Justin Reinicke, Charles J Simmons and 3 more

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Chalcones as Emerging Antibacterial Scaffolds: A Mini Review.Mini reviews in medicinal chemistry · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Mingming ZhangDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, Hawaii 96720, United States.
Allan M PriorDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, Hawaii 96720, United States.
Marcus M MaddoxDepartment of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS#1000, Memphis, Tennessee 38105, United States.
Wan-Jou ShenCenter for Infectious and Inflammatory Diseases, Texas A&M Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, United States.
Kirk E HevenerDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States.
David F BruhnDepartment of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS#1000, Memphis, Tennessee 38105, United States.
Robin B LeeDepartment of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS#1000, Memphis, Tennessee 38105, United States.
Aman P SinghDepartment of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS#1000, Memphis, Tennessee 38105, United States.
Justin ReinickeDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, Hawaii 96720, United States.
Charles J SimmonsDepartment of Chemistry, University of Hawai'i at Hilo, Hilo, Hawaii 96720, United States.
Julian G HurdleCenter for Infectious and Inflammatory Diseases, Texas A&M Health Science Center, 2121 West Holcombe Boulevard, Houston, Texas 77030, United States.
Richard E LeeDepartment of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS#1000, Memphis, Tennessee 38105, United States.
Dianqing SunDepartment of Pharmaceutical Sciences, The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, Hawaii 96720, United States.
St. Jude Children's Research Hospital · USUniversity of Hawaii at Hilo · USTexas A&M Health Science Center · USUniversity of Tennessee Health Science Center · US

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI Peter R Hoffmann · 2012 to 2026
$60.3M
Development of Piperidinols and Engelhardiones as Novel Antituberculosis AgentsR15AI092315 · NIAID · UNIVERSITY OF HAWAII AT HILO · PI SUN, DIANQING · 2011 to 2011
$406k
NIAID NIH HHS R15 AI092315NIGMS NIH HHS P20 GM103466
6 · The paper itself

Abstract

A series of novel chalcone and thiol-Michael addition analogues was synthesized and tested against

Identifiers

PMID30613820
PMCPMC6312637
OpenAlexW2905700246

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.